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UniProt functional annotation for P9WMN1 | ||
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| UniProt code: P9WMN1. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Function: | |
Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity). {ECO:0000250}. |
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| Catalytic activity: | |
Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho- alpha-D-ribose 1-diphosphate + ATP; Xref=Rhea:RHEA:18473, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:73183; EC=2.4.2.17; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| Activity regulation: | |
Feedback inhibited by histidine. Also inhibited by AMP. |
| Pathway: | |
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. |
| Subunit: | |
Equilibrium between an active dimeric form, an inactive hexameric form and higher aggregates. Interconversion between the various forms is largely reversible and is influenced by the natural substrates and inhibitors of the enzyme. {ECO:0000269|PubMed:12511575}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. |
| Similarity: | |
Belongs to the ATP phosphoribosyltransferase family. Long subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.