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UniProt functional annotation for P40460 | ||
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| UniProt code: P40460. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Acts as a component of the essential kinetochore-associated NDC80 complex, which is involved in chromosome segregation and spindle checkpoint activity. {ECO:0000269|PubMed:10409732, ECO:0000269|PubMed:11266451, ECO:0000269|PubMed:12514103, ECO:0000269|PubMed:9585415}. |
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| Subunit: | |
Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25. The NDC80 complex is formed by two subcomplexes, NDC80-NUF2 and SPC24-SPC25, which are joined end-to-end through their coiled-coil domains. It has a rod-like structure with a length of 570 Angstroms and globular domains at either end. The NDC80-NUF2 globular domains are probably directed to microtubules, the SPC24-SPC25 globular domains to the centromere. NDC80 probably interacts with SMC1 and SMC2. Also interacts with KIN3. Interacts with DMC1. {ECO:0000269|PubMed:10409732, ECO:0000269|PubMed:11179222, ECO:0000269|PubMed:11266451, ECO:0000269|PubMed:11952896, ECO:0000269|PubMed:12386167, ECO:0000269|PubMed:15371542, ECO:0000269|PubMed:9335591}. |
| Subcellular location: | |
Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores. |
| Miscellaneous: | |
Present with 1160 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the NDC80/HEC1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.