UniProt functional annotation for O55057



	UniProt functional annotation for O55057

UniProt code: O55057.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Promotes the release of prenylated target proteins from cellular membranes (PubMed:22179043). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22179043). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (PubMed:22179043). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate. {ECO:0000250|UniProtKB:O43924, ECO:0000250|UniProtKB:Q95142, ECO:0000269|PubMed:10518933, ECO:0000269|PubMed:15979089, ECO:0000269|PubMed:22179043}.

Subunit: Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains (PDE6A and PDE6B) and two inhibitory chains (gamma); has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane (By similarity). Interacts with prenylated GRK1 and GRK7 (By similarity). Interacts with prenylated INPP5E (By similarity). Interacts with prenylated Ras family members, including HRAS, KRAS, NRAS, RAP2A, RAP2C and RHEB (PubMed:22179043). Interacts with RAB13 (prenylated form); dissociates RAB13 from membranes (By similarity). Interacts with RPGR (PubMed:9990021). Interacts with ARL2 (PubMed:15979089). Interacts with ARL3; the interaction occurs specifically with the GTP-bound form of ARL3 (PubMed:15979089). Interaction with ARL2 and ARL3 promotes release of farnesylated cargo proteins (By similarity). {ECO:0000250|UniProtKB:O43924, ECO:0000250|UniProtKB:Q95142, ECO:0000269|PubMed:10518933, ECO:0000269|PubMed:15979089, ECO:0000269|PubMed:22179043, ECO:0000269|PubMed:9990021}.

Subcellular location: Cytoplasm, cytosol {ECO:0000269|PubMed:22179043}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O43924}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43924}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:O43924}.

Similarity: Belongs to the PDE6D/unc-119 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Promotes the release of prenylated target proteins from cellular membranes (PubMed:22179043). Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location (PubMed:22179043). Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (PubMed:22179043). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate. {ECO:0000250\|UniProtKB:O43924, ECO:0000250\|UniProtKB:Q95142, ECO:0000269\|PubMed:10518933, ECO:0000269\|PubMed:15979089, ECO:0000269\|PubMed:22179043}.


Subunit:		Interacts with the prenylated catalytic subunits of PDE6, an oligomer composed of two catalytic chains (PDE6A and PDE6B) and two inhibitory chains (gamma); has no effect on enzyme activity but promotes the release of the prenylated enzyme from cell membrane (By similarity). Interacts with prenylated GRK1 and GRK7 (By similarity). Interacts with prenylated INPP5E (By similarity). Interacts with prenylated Ras family members, including HRAS, KRAS, NRAS, RAP2A, RAP2C and RHEB (PubMed:22179043). Interacts with RAB13 (prenylated form); dissociates RAB13 from membranes (By similarity). Interacts with RPGR (PubMed:9990021). Interacts with ARL2 (PubMed:15979089). Interacts with ARL3; the interaction occurs specifically with the GTP-bound form of ARL3 (PubMed:15979089). Interaction with ARL2 and ARL3 promotes release of farnesylated cargo proteins (By similarity). {ECO:0000250\|UniProtKB:O43924, ECO:0000250\|UniProtKB:Q95142, ECO:0000269\|PubMed:10518933, ECO:0000269\|PubMed:15979089, ECO:0000269\|PubMed:22179043, ECO:0000269\|PubMed:9990021}.
Subcellular location:		Cytoplasm, cytosol {ECO:0000269\|PubMed:22179043}. Cytoplasmic vesicle membrane {ECO:0000250\|UniProtKB:O43924}; Peripheral membrane protein {ECO:0000250\|UniProtKB:O43924}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250\|UniProtKB:O43924}.
Similarity:		Belongs to the PDE6D/unc-119 family. {ECO:0000305}.