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UniProt functional annotation for O95696 | ||
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| UniProt code: O95696. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}. |
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| Subunit: | |
Component of some HBO1 complex composed of KAT7/HBO1, MEAF6, ING4 and BRD1/BRPF2 (PubMed:21753189, PubMed:28334966). Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3 (PubMed:16387653, PubMed:18794358). Interacts (via PHD-type zinc finger domain) with unmodified histone H3 (PubMed:21880731). Interacts (via PWWP domain) with dimethylated and trimethylated 'Lys-79' on histone H3 (PubMed:21720545). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:21720545, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731, ECO:0000269|PubMed:28334966}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}. Chromosome {ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:28334966}. Note=Localizes to transcription start sites. {ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:28334966}. |
| Tissue specificity: | |
Highly expressed in testis. {ECO:0000269|PubMed:10602503}. |
Annotations taken from UniProtKB at the EBI.