UniProt functional annotation for P62812



	UniProt functional annotation for P62812

UniProt code: P62812.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:27129275). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:27129275). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (PubMed:27129275). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:27129275). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (PubMed:25348603). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). {ECO:0000250|UniProtKB:P62813, ECO:0000269|PubMed:25348603, ECO:0000269|PubMed:27129275}.

Activity regulation: Allosterically activated by benzodiazepines, the neuroanesthetic alphaxalone and pentobarbital (By similarity). Inhibited by the antagonist bicuculline (By similarity). {ECO:0000250|UniProtKB:P14867, ECO:0000250|UniProtKB:P62813}.

Subunit: Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (By similarity). Interacts with UBQLN1 (By similarity). Interacts with TRAK1 (PubMed:16380713). Interacts with KIF21B (By similarity). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity). Interacts with LHFPL4 (By similarity). Interacts with NLGN2 (By similarity). Interacts with SHISA7; interaction leads to the regulation of GABA(A) receptor trafficking, channel deactivation kinetics and pharmacology (PubMed:31601770). {ECO:0000250|UniProtKB:P14867, ECO:0000250|UniProtKB:P62813, ECO:0000269|PubMed:16380713, ECO:0000269|PubMed:31601770}.

Subcellular location: Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:P08219}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:16380713, ECO:0000269|PubMed:25579817}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P62813}.

Domain: The extracellular domain contributes to synaptic contact formation. {ECO:0000269|PubMed:27129275}.

Ptm: Glycosylated. {ECO:0000269|PubMed:27129275}.

Disruption phenotype: Gene knockdown in orbitofrontal prefrontal cortex results in an inability of mice to select actions based on their consequences, developing instead habit-like behavioral inflexibility. {ECO:0000269|PubMed:25348603}.

Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub- subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:27129275). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:27129275). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (PubMed:27129275). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:27129275). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (PubMed:25348603). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). {ECO:0000250\|UniProtKB:P62813, ECO:0000269\|PubMed:25348603, ECO:0000269\|PubMed:27129275}.


Activity regulation:		Allosterically activated by benzodiazepines, the neuroanesthetic alphaxalone and pentobarbital (By similarity). Inhibited by the antagonist bicuculline (By similarity). {ECO:0000250\|UniProtKB:P14867, ECO:0000250\|UniProtKB:P62813}.
Subunit:		Heteropentamer, formed by a combination of alpha, beta, gamma, delta and rho chains (By similarity). Interacts with UBQLN1 (By similarity). Interacts with TRAK1 (PubMed:16380713). Interacts with KIF21B (By similarity). Identified in a complex of 720 kDa composed of LHFPL4, NLGN2, GABRA1, GABRB2, GABRG2 and GABRB3 (By similarity). Interacts with LHFPL4 (By similarity). Interacts with NLGN2 (By similarity). Interacts with SHISA7; interaction leads to the regulation of GABA(A) receptor trafficking, channel deactivation kinetics and pharmacology (PubMed:31601770). {ECO:0000250\|UniProtKB:P14867, ECO:0000250\|UniProtKB:P62813, ECO:0000269\|PubMed:16380713, ECO:0000269\|PubMed:31601770}.
Subcellular location:		Cell junction, synapse, postsynaptic cell membrane {ECO:0000250\|UniProtKB:P08219}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269\|PubMed:16380713, ECO:0000269\|PubMed:25579817}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250\|UniProtKB:P62813}.
Domain:		The extracellular domain contributes to synaptic contact formation. {ECO:0000269\|PubMed:27129275}.
Ptm:		Glycosylated. {ECO:0000269\|PubMed:27129275}.
Disruption phenotype:		Gene knockdown in orbitofrontal prefrontal cortex results in an inability of mice to select actions based on their consequences, developing instead habit-like behavioral inflexibility. {ECO:0000269\|PubMed:25348603}.
Similarity:		Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub- subfamily. {ECO:0000305}.