UniProt functional annotation for Q9NP92



	UniProt functional annotation for Q9NP92

UniProt code: Q9NP92.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Subunit: Component of the mitochondrial large ribosomal subunit (mt- LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL65 forms a heterodimer with mL37. {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.

Subcellular location: Mitochondrion {ECO:0000269|PubMed:11279123, ECO:0000269|PubMed:28892042}.

Tissue specificity: Heart, skeletal muscle, kidney and liver. Lower expression in placenta and peripheral blood leukocytes. {ECO:0000269|PubMed:10640817, ECO:0000269|PubMed:11279123}.

Similarity: Belongs to the mitochondrion-specific ribosomal protein mL65 family. {ECO:0000305}.

Sequence caution: Sequence=AAF67634.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAF67634.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.


Subunit:		Component of the mitochondrial large ribosomal subunit (mt- LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL65 forms a heterodimer with mL37. {ECO:0000269\|PubMed:25278503, ECO:0000269\|PubMed:25838379, ECO:0000269\|PubMed:28892042}.
Subcellular location:		Mitochondrion {ECO:0000269\|PubMed:11279123, ECO:0000269\|PubMed:28892042}.
Tissue specificity:		Heart, skeletal muscle, kidney and liver. Lower expression in placenta and peripheral blood leukocytes. {ECO:0000269\|PubMed:10640817, ECO:0000269\|PubMed:11279123}.
Similarity:		Belongs to the mitochondrion-specific ribosomal protein mL65 family. {ECO:0000305}.
Sequence caution:		Sequence=AAF67634.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAF67634.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};