UniProt functional annotation for Q13084



	UniProt functional annotation for Q13084

UniProt code: Q13084.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Subunit: Component of the mitochondrial large ribosomal subunit (mt- LSU) (PubMed:28892042, PubMed:25278503, PubMed:11551941). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:11551941, PubMed:25278503). Interacts with OXA1L. {ECO:0000250|UniProtKB:Q2HJJ1, ECO:0000269|PubMed:11551941, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:28892042, ECO:0000305|PubMed:11551941}.

Subcellular location: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:28892042}.

Tissue specificity: Found in a variety of normal tissues including spleen, testes, thymus, liver, kidney, brain, adrenal, lung and retinal tissue.

Miscellaneous: Potentially represents an important therapeutic reagent for HLA-A24 patients. This antigen is recognized by tumor-infiltrating lymphocyte (TIL) 1290 in the context of HLA-A24.

Similarity: Belongs to the bacterial ribosomal protein bL28 family. {ECO:0000305}.

Sequence caution: Sequence=AAC50181.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK61226.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.


Subunit:		Component of the mitochondrial large ribosomal subunit (mt- LSU) (PubMed:28892042, PubMed:25278503, PubMed:11551941). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:11551941, PubMed:25278503). Interacts with OXA1L. {ECO:0000250\|UniProtKB:Q2HJJ1, ECO:0000269\|PubMed:11551941, ECO:0000269\|PubMed:25278503, ECO:0000269\|PubMed:28892042, ECO:0000305\|PubMed:11551941}.
Subcellular location:		Mitochondrion {ECO:0000269\|PubMed:25278503, ECO:0000269\|PubMed:28892042}.
Tissue specificity:		Found in a variety of normal tissues including spleen, testes, thymus, liver, kidney, brain, adrenal, lung and retinal tissue.
Miscellaneous:		Potentially represents an important therapeutic reagent for HLA-A24 patients. This antigen is recognized by tumor-infiltrating lymphocyte (TIL) 1290 in the context of HLA-A24.
Similarity:		Belongs to the bacterial ribosomal protein bL28 family. {ECO:0000305}.
Sequence caution:		Sequence=AAC50181.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK61226.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};