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UniProt functional annotation for L0R8F8 | ||
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| UniProt code: L0R8F8. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Involved in the regulation of mitochondrial fission mediated by DNM1L (PubMed:29083303). Positively regulates mitochondrial translation (PubMed:30215512). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). {ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:30215512, ECO:0000305|PubMed:28892042}. |
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| Subunit: | |
Identified in a complex composed of MALSU1, MIEF1 upstream open reading frame protein and NDUFAB1; within the trimeric complex, MIEF1 upstream open reading frame protein functions as a bridging scaffold that interacts with MALSU1 on one side, and with NDUFAB1 on the other side (PubMed:28892042, PubMed:30215512). Within the complex, MALSU1 mediates interaction with the mitochondrial large ribosomal subunit (PubMed:28892042). Interacts with ribosomal proteins MRPL4 and MRPS27 (PubMed:30215512). {ECO:0000269|PubMed:28892042, ECO:0000269|PubMed:30215512}. |
| Subcellular location: | |
Mitochondrion matrix {ECO:0000269|PubMed:28892042, ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:30215512}. |
| Miscellaneous: | |
[Isoform 3]: Product of the upstream open reading frame of this bicistronic gene. {ECO:0000305|PubMed:25621764}. |
| Similarity: | |
Belongs to the complex I LYR family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.