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UniProt functional annotation for P40107 | ||
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| UniProt code: P40107. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Defective copy causes severe glycosylation defect and abnormal retention of soluble endoplasmic reticulum proteins. Involved in vanadate sensitivity. {ECO:0000269|PubMed:10570930, ECO:0000269|PubMed:11067855, ECO:0000269|PubMed:12478588, ECO:0000269|PubMed:15494368, ECO:0000269|PubMed:2014241, ECO:0000269|PubMed:2137555, ECO:0000269|PubMed:7672592, ECO:0000269|PubMed:7877969, ECO:0000269|PubMed:8632002, ECO:0000269|PubMed:9184829, ECO:0000269|PubMed:9335583, ECO:0000269|PubMed:9395539}. |
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| Subunit: | |
Homooligomer. {ECO:0000269|PubMed:10570930, ECO:0000269|PubMed:11067855}. |
| Subcellular location: | |
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Recycles between the Golgi apparatus and the endoplasmic reticulum. |
| Miscellaneous: | |
Present with 31900 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the TPT transporter family. SLC35D subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.