UniProt functional annotation for Q05209



	UniProt functional annotation for Q05209

UniProt code: Q05209.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}.

Catalytic activity: Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE- ProRule:PRU10044, ECO:0000269|PubMed:27134172, ECO:0000269|PubMed:8454633};

Subunit: Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1 (PubMed:9857189). Interacts with PTK2B/PYK2 (PubMed:17329398). Interacts with LPXN (By similarity). Interacts with SORBS2; this interaction greatly enhances WASF1 dephosphorylation and might mediate partial translocation to focal adhesion sites (PubMed:18559503). {ECO:0000250|UniProtKB:P35831, ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9857189}.

Subcellular location: Cytoplasm {ECO:0000250|UniProtKB:P35831}. Cell junction, focal adhesion {ECO:0000269|PubMed:18559503}. Cell projection, podosome {ECO:0000250|UniProtKB:P35831}. Note=Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2. {ECO:0000269|PubMed:18559503}.

Ptm: Phosphorylated by STK24/MST3 and this results in inhibition of its activity. {ECO:0000269|PubMed:17046825}.

Similarity: Belongs to the protein-tyrosine phosphatase family. Non- receptor class 4 subfamily. {ECO:0000305}.

Sequence caution: Sequence=BAD92761.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269\|PubMed:17329398, ECO:0000269\|PubMed:18559503, ECO:0000269\|PubMed:27134172}.


Catalytic activity:		Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255\|PROSITE- ProRule:PRU10044, ECO:0000269\|PubMed:27134172, ECO:0000269\|PubMed:8454633};
Subunit:		Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1 (PubMed:9857189). Interacts with PTK2B/PYK2 (PubMed:17329398). Interacts with LPXN (By similarity). Interacts with SORBS2; this interaction greatly enhances WASF1 dephosphorylation and might mediate partial translocation to focal adhesion sites (PubMed:18559503). {ECO:0000250\|UniProtKB:P35831, ECO:0000269\|PubMed:17329398, ECO:0000269\|PubMed:18559503, ECO:0000269\|PubMed:9857189}.
Subcellular location:		Cytoplasm {ECO:0000250\|UniProtKB:P35831}. Cell junction, focal adhesion {ECO:0000269\|PubMed:18559503}. Cell projection, podosome {ECO:0000250\|UniProtKB:P35831}. Note=Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2. {ECO:0000269\|PubMed:18559503}.
Ptm:		Phosphorylated by STK24/MST3 and this results in inhibition of its activity. {ECO:0000269\|PubMed:17046825}.
Similarity:		Belongs to the protein-tyrosine phosphatase family. Non- receptor class 4 subfamily. {ECO:0000305}.
Sequence caution:		Sequence=BAD92761.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};