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PDBsum entry 5nip
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References listed in PDB file
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Key reference
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Title
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The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-Motif structures.
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Authors
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B.Mir,
X.Solés,
C.González,
N.Escaja.
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Ref.
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Sci Rep, 2017,
7,
2772.
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PubMed id
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Abstract
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Incorporation of pseudoisocytidine (psC), a neutral analogue of protonated
cytidine, in i-motifs has been studied by spectroscopic methods. Our results
show that neutral psC:C base pairs can stabilize i-motifs at neutral pH, but the
stabilization only occurs when psC:C base pairs are located at the ends of
intercalated C:C+stacks. When psC occupies central positions, the
resulting i-motifs are only observed at low pH and psC:C+or
psC:psC+hemiprotonated base pairs are formed instead of their neutral
analogs. Overall, our results suggest that positively charged base pairs are
necessary to stabilize this non-canonical DNA structure.
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Headers
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