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UniProt functional annotation for Q4FQF7 | ||
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| UniProt code: Q4FQF7. |
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| Organism: | |
Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Psychrobacter. |
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| Function: | |
Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. {ECO:0000255|HAMAP-Rule:MF_01018}. |
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| Catalytic activity: | |
Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho- alpha-D-ribose 1-diphosphate + ATP; Xref=Rhea:RHEA:18473, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:73183; EC=2.4.2.17; Evidence={ECO:0000255|HAMAP- Rule:MF_01018}; |
| Pathway: | |
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. {ECO:0000255|HAMAP-Rule:MF_01018}. |
| Subunit: | |
Heteromultimer composed of HisG and HisZ subunits. {ECO:0000255|HAMAP-Rule:MF_01018}. |
| Subcellular location: | |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01018}. |
| Domain: | |
Lacks the C-terminal regulatory region which is replaced by HisZ. |
| Similarity: | |
Belongs to the ATP phosphoribosyltransferase family. Short subfamily. {ECO:0000255|HAMAP-Rule:MF_01018}. |
Annotations taken from UniProtKB at the EBI.