UniProt functional annotation for P37613



	UniProt functional annotation for P37613

UniProt code: P37613.

Organism: Escherichia coli (strain K12).

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.

Function: Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion. Binding of CoA or a derivative to PanZ leads to interaction with PanD, which promotes the processing and activation of pro-PanD, and subsequent substrate-mediated inhibition of the active form of PanD (PubMed:23170229, PubMed:25910242). Inhibition of PanD activity is probably the primary metabolic role of PanZ, allowing negative feedback regulation of pantothenate biosynthesis by CoA (PubMed:25910242). {ECO:0000269|PubMed:23170229, ECO:0000269|PubMed:25910242}.

Activity regulation: Activation of PanD processing occurs even at low CoA concentrations. In contrast, full inhibition of PanD catalytic activity only occurs at sufficiently high CoA concentrations. {ECO:0000269|PubMed:25910242}.

Subunit: Interacts with PanD in the presence of CoA (PubMed:23170229, PubMed:22940551, PubMed:25910242). Forms a heterooctameric complex composed of four PanD subunits and four PanZ subunits (PubMed:22940551, PubMed:25910242). Monomer in solution (PubMed:22940551). {ECO:0000269|PubMed:22940551, ECO:0000269|PubMed:23170229, ECO:0000269|PubMed:25910242}.

Disruption phenotype: Deletion mutants are deficient in the biosynthetic pathway for pantothenate. {ECO:0000269|PubMed:23170229}.

Similarity: Belongs to the PanZ/PanM family. {ECO:0000255|HAMAP- Rule:MF_02018, ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Escherichia coli (strain K12).
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.



Function:		Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion. Binding of CoA or a derivative to PanZ leads to interaction with PanD, which promotes the processing and activation of pro-PanD, and subsequent substrate-mediated inhibition of the active form of PanD (PubMed:23170229, PubMed:25910242). Inhibition of PanD activity is probably the primary metabolic role of PanZ, allowing negative feedback regulation of pantothenate biosynthesis by CoA (PubMed:25910242). {ECO:0000269\|PubMed:23170229, ECO:0000269\|PubMed:25910242}.


Activity regulation:		Activation of PanD processing occurs even at low CoA concentrations. In contrast, full inhibition of PanD catalytic activity only occurs at sufficiently high CoA concentrations. {ECO:0000269\|PubMed:25910242}.
Subunit:		Interacts with PanD in the presence of CoA (PubMed:23170229, PubMed:22940551, PubMed:25910242). Forms a heterooctameric complex composed of four PanD subunits and four PanZ subunits (PubMed:22940551, PubMed:25910242). Monomer in solution (PubMed:22940551). {ECO:0000269\|PubMed:22940551, ECO:0000269\|PubMed:23170229, ECO:0000269\|PubMed:25910242}.
Disruption phenotype:		Deletion mutants are deficient in the biosynthetic pathway for pantothenate. {ECO:0000269\|PubMed:23170229}.
Similarity:		Belongs to the PanZ/PanM family. {ECO:0000255\|HAMAP- Rule:MF_02018, ECO:0000305}.