UniProt functional annotation for Q5SHR1



	UniProt functional annotation for Q5SHR1

UniProt code: Q5SHR1.

Organism: Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).

Taxonomy: Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.

Function: One of the essential components for the initiation of protein synthesis. Binds in the vicinity of the A-site (ECO:0000269|PubMed:11228145). Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. {ECO:0000255|HAMAP-Rule:MF_00075, ECO:0000269|PubMed:11228145}.

Subunit: Binds to the 30S ribosomal subunit, contacting protein S12 and the 16S rRNA (ECO:0000269|PubMed:11228145). Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl- tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly. {ECO:0000255|HAMAP-Rule:MF_00075, ECO:0000269|PubMed:11228145}.

Subcellular location: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00075}.

Similarity: Belongs to the IF-1 family. {ECO:0000255|HAMAP- Rule:MF_00075}.

Annotations taken from UniProtKB at the EBI.


Organism:		Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
Taxonomy:		Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.



Function:		One of the essential components for the initiation of protein synthesis. Binds in the vicinity of the A-site (ECO:0000269\|PubMed:11228145). Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. {ECO:0000255\|HAMAP-Rule:MF_00075, ECO:0000269\|PubMed:11228145}.


Subunit:		Binds to the 30S ribosomal subunit, contacting protein S12 and the 16S rRNA (ECO:0000269\|PubMed:11228145). Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl- tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly. {ECO:0000255\|HAMAP-Rule:MF_00075, ECO:0000269\|PubMed:11228145}.
Subcellular location:		Cytoplasm {ECO:0000255\|HAMAP-Rule:MF_00075}.
Similarity:		Belongs to the IF-1 family. {ECO:0000255\|HAMAP- Rule:MF_00075}.