UniProt functional annotation for P80373

UniProt codes: P80373, Q5SHR5.

Organism:		Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8).
Taxonomy:		Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
Function:		One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the body and platform of the 30S subunit. Binds mRNA in the 70S ribosome, positioning it for translation. {ECO:0000269|PubMed:11866529}.
Cofactor:		Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:11866529}; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000269|PubMed:25775268, ECO:0000269|PubMed:26792896}; Note=Binds 1 zinc ion per subunit (PubMed:11866529). In a number of structures (e.g. 4Y4O, 5FDV) a 4Fe-4S cluster is seen in place of the zinc cofactor (PubMed:25775268, PubMed:26792896). {ECO:0000269|PubMed:11866529, ECO:0000269|PubMed:25775268, ECO:0000269|PubMed:26792896};
Subunit:		Part of the 30S ribosomal subunit (PubMed:11014182, PubMed:11007480, PubMed:11163189, PubMed:11014183, PubMed:11511350, PubMed:11296217, PubMed:11228145, PubMed:11228145, PubMed:11283358, PubMed:11340196, PubMed:11866529, PubMed:25775268, PubMed:26792896). Contacts protein S5 (PubMed:11340196). The interaction surface between S4 and S5 is involved in control of translational fidelity. {ECO:0000269|PubMed:11007480, ECO:0000269|PubMed:11014182, ECO:0000269|PubMed:11014183, ECO:0000269|PubMed:11163189, ECO:0000269|PubMed:11228145, ECO:0000269|PubMed:11283358, ECO:0000269|PubMed:11296217, ECO:0000269|PubMed:11340196, ECO:0000269|PubMed:11511350, ECO:0000269|PubMed:11866529, ECO:0000269|PubMed:25775268, ECO:0000269|PubMed:26792896}.
Mass spectrometry:		Mass=24192; Method=MALDI; Evidence={ECO:0000269|PubMed:16287167};
Similarity:		Belongs to the universal ribosomal protein uS4 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.