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UniProt functional annotation for P00336 | ||
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| UniProt code: P00336. |
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| Organism: | |
Sus scrofa (Pig). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. |
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| Catalytic activity: | |
Reaction=(S)-lactate + NAD(+) = H(+) + NADH + pyruvate; Xref=Rhea:RHEA:23444, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16651, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.27; Evidence={ECO:0000250|UniProtKB:P07195}; |
| Pathway: | |
Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. |
| Subunit: | |
Homotetramer (PubMed:7338899). Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria (By similarity). {ECO:0000250|UniProtKB:P07195, ECO:0000269|PubMed:7338899}. |
| Subcellular location: | |
Cytoplasm. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07195}; Peripheral membrane protein {ECO:0000305}. |
| Similarity: | |
Belongs to the LDH/MDH superfamily. LDH family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.