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UniProt functional annotation for Q8EEB0 | ||
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| UniProt code: Q8EEB0. |
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| Organism: | |
Shewanella oneidensis (strain MR-1). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales; Shewanellaceae; Shewanella. |
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| Function: | |
Catalyzes the first step of the biosynthesis of Kdo8N (8- amino-3,8-dideoxy-D-manno-octulosonate) from Kdo (3-deoxy-D-manno- octulosonate). {ECO:0000269|PubMed:23413030}. |
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| Catalytic activity: | |
Reaction=3-deoxy-alpha-D-manno-oct-2-ulosonate + O2 = 3,8-dideoxy-8- oxo-alpha-D-manno-octulosonate + H2O2; Xref=Rhea:RHEA:46888, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:85986, ChEBI:CHEBI:87090; EC=1.1.3.48; Evidence={ECO:0000269|PubMed:23413030}; |
| Cofactor: | |
Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Evidence={ECO:0000269|PubMed:23413030}; Note=Shows highest activity with Mn(2+) and Fe(2+). {ECO:0000269|PubMed:23413030}; |
| Activity regulation: | |
Inhibited by EDTA. {ECO:0000269|PubMed:23413030}. |
| Pathway: | |
Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. {ECO:0000269|PubMed:23413030}. |
| Disruption phenotype: | |
A double kdnA/kdnB deletion mutant shows increased sensitivity to polymyxin B and bile salts. {ECO:0000269|PubMed:23413030}. |
| Miscellaneous: | |
Kdo8N is found in lipopolysaccharides of members of the Shewanella genus. {ECO:0000305|PubMed:23413030}. |
| Similarity: | |
Belongs to the iron-containing alcohol dehydrogenase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.