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UniProt functional annotation for K7IM66 | ||
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| UniProt code: K7IM66. |
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| Organism: | |
Nasonia vitripennis (Parasitic wasp). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Hymenoptera; Apocrita; Parasitoida; Chalcidoidea; Pteromalidae; Pteromalinae; Nasonia. |
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| Function: | |
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7- methylguanosine cap of a subset of mRNAs. {ECO:0000255|HAMAP- Rule:MF_03003}. |
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| Subunit: | |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. {ECO:0000255, ECO:0000255|HAMAP-Rule:MF_03003}. |
| Subcellular location: | |
Cytoplasm {ECO:0000255, ECO:0000255|HAMAP- Rule:MF_03003}. |
| Domain: | |
The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex. {ECO:0000305|PubMed:27462815}. |
| Similarity: | |
Belongs to the eIF-3 subunit D family. {ECO:0000255, ECO:0000255|HAMAP-Rule:MF_03003}. |
Annotations taken from UniProtKB at the EBI.