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UniProt functional annotation for Q9BPX1 | ||
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| UniProt code: Q9BPX1. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro). {ECO:0000269|PubMed:17067289}. |
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| Catalytic activity: | |
Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH; Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469, ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62; Evidence={ECO:0000269|PubMed:17067289}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24613; Evidence={ECO:0000305|PubMed:17067289}; |
| Catalytic activity: | |
Reaction=androst-5-en-3beta,17beta-diol + NAD(+) = 3beta- hydroxyandrost-5-en-17-one + H(+) + NADH; Xref=Rhea:RHEA:46220, ChEBI:CHEBI:2710, ChEBI:CHEBI:15378, ChEBI:CHEBI:28689, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; Evidence={ECO:0000269|PubMed:17067289}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46221; Evidence={ECO:0000305|PubMed:17067289}; |
| Subunit: | |
Homotetramer. {ECO:0000269|PubMed:17067289}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:17067289}. |
| Tissue specificity: | |
Highly expressed in brain, placenta, liver and kidney. {ECO:0000269|PubMed:10800688, ECO:0000269|PubMed:17067289}. |
| Similarity: | |
Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.