UniProt functional annotation for F7BJB9



	UniProt functional annotation for F7BJB9

UniProt code: F7BJB9.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (By similarity). Sumoylated MORC3-NBs can also associate with PML-NBs (By similarity). Recruits TP53 and SP100 to PML- NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (By similarity). Histone methylation reader which binds to non- methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (By similarity). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (By similarity). {ECO:0000250|UniProtKB:Q14149, ECO:0000269|PubMed:17332504}.

Subunit: Homodimer. The sumoylated form interacts with PML (via SUMO- interacting motif). Interacts with PT53. {ECO:0000269|PubMed:17332504}.

Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:17332504}. Nucleus matrix {ECO:0000250|UniProtKB:Q14149}. Nucleus, PML body {ECO:0000269|PubMed:17332504}. Note=Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent. {ECO:0000250|UniProtKB:Q14149}.

Domain: The CW-TYPE zinc finger mediates its binding to trimethylated histone H3K4me3. {ECO:0000250|UniProtKB:Q14149}.

Ptm: Sumoylation is involved in interaction with PML and localization to PML nuclear bodies. {ECO:0000250|UniProtKB:Q14149}.

Disruption phenotype: Lethality occurs at birth or within a day thereafter, for unknown reasons. Embryos at 14.5 dpc are morphologically indistinguishable from wild type. {ECO:0000269|PubMed:17332504}.

Sequence caution: Sequence=BAD32174.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (By similarity). Sumoylated MORC3-NBs can also associate with PML-NBs (By similarity). Recruits TP53 and SP100 to PML- NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (By similarity). Histone methylation reader which binds to non- methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (By similarity). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (By similarity). {ECO:0000250\|UniProtKB:Q14149, ECO:0000269\|PubMed:17332504}.


Subunit:		Homodimer. The sumoylated form interacts with PML (via SUMO- interacting motif). Interacts with PT53. {ECO:0000269\|PubMed:17332504}.
Subcellular location:		Nucleus, nucleoplasm {ECO:0000269\|PubMed:17332504}. Nucleus matrix {ECO:0000250\|UniProtKB:Q14149}. Nucleus, PML body {ECO:0000269\|PubMed:17332504}. Note=Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent. {ECO:0000250\|UniProtKB:Q14149}.
Domain:		The CW-TYPE zinc finger mediates its binding to trimethylated histone H3K4me3. {ECO:0000250\|UniProtKB:Q14149}.
Ptm:		Sumoylation is involved in interaction with PML and localization to PML nuclear bodies. {ECO:0000250\|UniProtKB:Q14149}.
Disruption phenotype:		Lethality occurs at birth or within a day thereafter, for unknown reasons. Embryos at 14.5 dpc are morphologically indistinguishable from wild type. {ECO:0000269\|PubMed:17332504}.
Sequence caution:		Sequence=BAD32174.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};