UniProt functional annotation for P35747



	UniProt functional annotation for P35747

UniProt code: P35747.

Organism: Equus caballus (Horse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.

Function: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity). {ECO:0000250|UniProtKB:P02768, ECO:0000250|UniProtKB:P02769}.

Subunit: Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity). Interacts with TASOR (By similarity). {ECO:0000250|UniProtKB:P02768, ECO:0000250|UniProtKB:P07724}.

Subcellular location: Secreted.

Tissue specificity: Plasma.

Ptm: Phosphorylated by FAM20C in the extracellular medium. {ECO:0000250|UniProtKB:P02768}.

Allergen: Can cause allergic reactions in humans. Binds to IgE.

Similarity: Belongs to the ALB/AFP/VDB family. {ECO:0000255|PROSITE- ProRule:PRU00769}.

Annotations taken from UniProtKB at the EBI.


Organism:		Equus caballus (Horse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.



Function:		Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity). {ECO:0000250\|UniProtKB:P02768, ECO:0000250\|UniProtKB:P02769}.


Subunit:		Interacts with FCGRT; this interaction regulates ALB homeostasis (By similarity). Interacts with TASOR (By similarity). {ECO:0000250\|UniProtKB:P02768, ECO:0000250\|UniProtKB:P07724}.
Subcellular location:		Secreted.
Tissue specificity:		Plasma.
Ptm:		Phosphorylated by FAM20C in the extracellular medium. {ECO:0000250\|UniProtKB:P02768}.
Allergen:		Can cause allergic reactions in humans. Binds to IgE.
Similarity:		Belongs to the ALB/AFP/VDB family. {ECO:0000255\|PROSITE- ProRule:PRU00769}.