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UniProt functional annotation for P21375 | ||
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| UniProt code: P21375. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Irreversibly catalyzes the reduction of fumarate to succinate. Together with the second isozyme of soluble fumarate reductase (FRD1), essential for anaerobic growth. Involved in maintaining redox balance during oxygen deficiency conditions. Reduction of fumarate is the main source of succinate during fermentation, and under anaerobic conditions, the formation of succinate is strictly required for the reoxidation of FADH(2). {ECO:0000269|PubMed:12949191, ECO:0000269|PubMed:17345583, ECO:0000269|PubMed:9587404, ECO:0000269|PubMed:9711846}. |
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| Catalytic activity: | |
Reaction=NAD(+) + succinate = fumarate + H(+) + NADH; Xref=Rhea:RHEA:18281, ChEBI:CHEBI:15378, ChEBI:CHEBI:29806, ChEBI:CHEBI:30031, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.3.1.6; Evidence={ECO:0000269|PubMed:9587404}; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000269|PubMed:9587404}; Note=Binds 1 FAD per monomer. {ECO:0000269|PubMed:9587404}; |
| Subcellular location: | |
Mitochondrion {ECO:0000269|PubMed:9587404}. |
| Disruption phenotype: | |
Causes increased sensitivity to hypertonic growth medium. {ECO:0000269|PubMed:211068}. |
| Miscellaneous: | |
Present with 432 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAB59346.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.