UniProt functional annotation for A4IKE7



	UniProt functional annotation for A4IKE7

UniProt code: A4IKE7.

Organism: Geobacillus thermodenitrificans (strain NG80-2).

Taxonomy: Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.

Function: Part of the ESX specialized secretion system, which exports proteins from the cell including EsxA (ESAT-6) and EsxB (CFP-10) (By similarity). Might be the translocase subunit (PubMed:25865481). Probably only the first FtsK domain can hydrolyze ATP (PubMed:27130157). {ECO:0000250|UniProtKB:P9WNB1, ECO:0000250|UniProtKB:P9WNB3, ECO:0000305|PubMed:25865481, ECO:0000305|PubMed:27130157}.

Activity regulation: EsxB binding to the third FtsK domain causes multimerization; a subsequent unknown step relieves the allosteric inhibition of linker 2 on FtsK domain 1, activating the ATPase activity (By similarity). {ECO:0000250|UniProtKB:D1A4G7}.

Subunit: Whole protein oligomerizes in native gels (PubMed:27130157). Part of the ESX / type VII secretion system (T7SS), which is composed of cytosolic and membrane components. The ESX membrane complex is composed of EccB, EccC and EccD (By similarity). {ECO:0000250|UniProtKB:P9WNB1, ECO:0000250|UniProtKB:P9WNB3, ECO:0000269|PubMed:27130157}.

Subcellular location: Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.

Domain: The cytoplasmic domain is a rigid structure with 4 domains (residues 480 to 599 form an unnamed domain) plus the 3 FtsK (ATPase) domains which are connected by short linkers (PubMed:25865481).

Miscellaneous: Unlike the well characterized M.tuberculosis ESX-1 cluster, this protein is not split into 2 genes. This subunit and a WGX100 family protein are the only proteins universally associated with T7SS. {ECO:0000305|PubMed:25865481}.

Annotations taken from UniProtKB at the EBI.


Organism:		Geobacillus thermodenitrificans (strain NG80-2).
Taxonomy:		Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.



Function:		Part of the ESX specialized secretion system, which exports proteins from the cell including EsxA (ESAT-6) and EsxB (CFP-10) (By similarity). Might be the translocase subunit (PubMed:25865481). Probably only the first FtsK domain can hydrolyze ATP (PubMed:27130157). {ECO:0000250\|UniProtKB:P9WNB1, ECO:0000250\|UniProtKB:P9WNB3, ECO:0000305\|PubMed:25865481, ECO:0000305\|PubMed:27130157}.


Activity regulation:		EsxB binding to the third FtsK domain causes multimerization; a subsequent unknown step relieves the allosteric inhibition of linker 2 on FtsK domain 1, activating the ATPase activity (By similarity). {ECO:0000250\|UniProtKB:D1A4G7}.
Subunit:		Whole protein oligomerizes in native gels (PubMed:27130157). Part of the ESX / type VII secretion system (T7SS), which is composed of cytosolic and membrane components. The ESX membrane complex is composed of EccB, EccC and EccD (By similarity). {ECO:0000250\|UniProtKB:P9WNB1, ECO:0000250\|UniProtKB:P9WNB3, ECO:0000269\|PubMed:27130157}.
Subcellular location:		Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
Domain:		The cytoplasmic domain is a rigid structure with 4 domains (residues 480 to 599 form an unnamed domain) plus the 3 FtsK (ATPase) domains which are connected by short linkers (PubMed:25865481).
Miscellaneous:		Unlike the well characterized M.tuberculosis ESX-1 cluster, this protein is not split into 2 genes. This subunit and a WGX100 family protein are the only proteins universally associated with T7SS. {ECO:0000305\|PubMed:25865481}.