spacer
spacer

PDBsum entry 5ekd
Go to PDB code: 
protein ligands metals Protein-protein interface(s) links
Ligase/antibiotic PDB id
5ekd

 

 

 

 

Loading ...

 
JSmol PyMol  
Contents
Protein chains
327 a.a.
Ligands
5BX ×2
ATP ×2
GOL ×2
Metals
_MN ×4
Waters ×541
PDB id:
5ekd
Name: Ligase/antibiotic
Title: Human mitochondrial tryptophanyl-tRNA synthetase bound by indolmycin and mn Atp.
Structure: Tryptophan--tRNA ligase, mitochondrial. Chain: a, b. Synonym: (mt)trprs,tryptophanyl-tRNA synthetase,trprs. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: wars2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.82Å     R-factor:   0.172     R-free:   0.207
Authors: T.L.Williams,C.W.Carter Jr.
Key ref: T.L.Williams and c.w.jr.carter Binding of mg2+ATP enhances inhibition of human mitochondrial tryptophanyl-Trna synthetase by indolmy. To be published, .
Date:
03-Nov-15     Release date:   16-Nov-16    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q9UGM6  (SYWM_HUMAN) -  Tryptophan--tRNA ligase, mitochondrial from Homo sapiens
Seq:
Struc: 		360 a.a.
327 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.6.1.1.2  - tryptophan--tRNA ligase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H+
tRNA(Trp)
Bound ligand (Het Group name = ATP)
corresponds exactly 		+
L-tryptophan
Bound ligand (Het Group name = 5BX)
matches with 61.90% similarity 		+ ATP
 = L-tryptophyl-tRNA(Trp)
 + AMP
 + diphosphate
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

spacer
spacer