UniProt functional annotation for Q06528



	UniProt functional annotation for Q06528

UniProt code: Q06528.

Organism: Streptomyces peucetius.

Taxonomy: Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces.

Function: Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. In vivo, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the 4-O- position of carminomycin to form daunorubicin. In vitro, it also methylates the anthracyclines rhodomycin D (10-carbomethoxy-13- deoxycarminomycin) and 13-deoxy-carminomycin at the 4-hydroxyl position. It is quite specific with respect to the length of the carbohydrate chain at the C7 position, but it can accept substrates with bulky substituent at C10 position. {ECO:0000269|PubMed:15273252}.

Catalytic activity: Reaction=carminomycin + S-adenosyl-L-methionine = daunorubicin + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:38311, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64677, ChEBI:CHEBI:75730; EC=2.1.1.292; Evidence={ECO:0000269|PubMed:15273252};

Pathway: Antibiotic biosynthesis; daunorubicin biosynthesis.

Pathway: Antibiotic biosynthesis; carminomycin biosynthesis.

Subunit: Homodimer and homotetramer in equilibrium. {ECO:0000269|PubMed:15273252}.

Similarity: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. {ECO:0000255|PROSITE-ProRule:PRU01020}.

Annotations taken from UniProtKB at the EBI.


Organism:		Streptomyces peucetius.
Taxonomy:		Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces.



Function:		Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. In vivo, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the 4-O- position of carminomycin to form daunorubicin. In vitro, it also methylates the anthracyclines rhodomycin D (10-carbomethoxy-13- deoxycarminomycin) and 13-deoxy-carminomycin at the 4-hydroxyl position. It is quite specific with respect to the length of the carbohydrate chain at the C7 position, but it can accept substrates with bulky substituent at C10 position. {ECO:0000269\|PubMed:15273252}.


Catalytic activity:		Reaction=carminomycin + S-adenosyl-L-methionine = daunorubicin + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:38311, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64677, ChEBI:CHEBI:75730; EC=2.1.1.292; Evidence={ECO:0000269\|PubMed:15273252};
Pathway:		Antibiotic biosynthesis; daunorubicin biosynthesis.
Pathway:		Antibiotic biosynthesis; carminomycin biosynthesis.
Subunit:		Homodimer and homotetramer in equilibrium. {ECO:0000269\|PubMed:15273252}.
Similarity:		Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. {ECO:0000255\|PROSITE-ProRule:PRU01020}.