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PDBsum entry 5e5e
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References listed in PDB file
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Key reference
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Title
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Cytotoxic properties of a new organometallic platinum(ii) complex and its gold(i) heterobimetallic derivatives.
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Authors
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M.Serratrice,
L.Maiore,
A.Zucca,
S.Stoccoro,
I.Landini,
E.Mini,
L.Massai,
G.Ferraro,
A.Merlino,
L.Messori,
M.A.Cinellu.
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Ref.
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Dalton Trans, 2016,
45,
579-590.
[DOI no: ]
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PubMed id
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Abstract
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A novel platinum(ii) organometallic complex, [Pt(pbi)(Me)(DMSO)], bearing the
2-(2'-pyridyl)-benzimidazole (pbiH) ligand, was synthesized and fully
characterized. Interestingly, the reaction of this organometallic platinum(ii)
complex with two distinct gold(i) phosphane compounds afforded the corresponding
heterobimetallic derivatives with the pbi ligand bridging the two metal centers.
The antiproliferative properties in vitro of [Pt(pbi)(Me)(DMSO)] and its gold(i)
derivatives as well as those of the known coordination platinum(ii) and
palladium(ii) complexes with the same ligand, of the general formula
[MCl2(pbiH)], were comparatively evaluated against A2780 cancer cells, either
sensitive or resistant to cisplatin. A superior biological activity of the
organometallic compound clearly emerged compared to the corresponding
platinum(ii) complex; the antiproliferative effects are further enhanced upon
attaching the gold(i) triphenylphosphine moiety to the organometallic Pt
compound. Remarkably, these novel metal species are able to overcome nearly
complete resistance to cisplatin. Significant mechanistic insight into the study
compounds was gained after investigating their reactions with a few
representative biomolecules by electrospray mass spectrometry and X-ray
crystallography. The obtained results are comprehensively discussed.
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