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UniProt functional annotation for P0A6R3 | ||
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| UniProt code: P0A6R3. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin- mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT- rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome (PubMed:16963779). {ECO:0000269|PubMed:16963779, ECO:0000269|PubMed:2209559, ECO:0000269|PubMed:8836178}. |
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| Subunit: | |
Homodimer. |
| Subcellular location: | |
Cytoplasm, nucleoid {ECO:0000269|PubMed:21903814}. Note=Scattered throughout the nucleoid (PubMed:21903814). {ECO:0000269|PubMed:21903814}. |
| Similarity: | |
Belongs to the transcriptional regulatory Fis family. {ECO:0000255|HAMAP-Rule:MF_00166}. |
Annotations taken from UniProtKB at the EBI.