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UniProt functional annotation for Q9Z1W9 | ||
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| UniProt code: Q9Z1W9. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation (PubMed:21317537, PubMed:23542070). Phosphorylates RELT (PubMed:16530727). {ECO:0000269|PubMed:16530727, ECO:0000269|PubMed:21317537, ECO:0000269|PubMed:23542070}. |
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| Catalytic activity: | |
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; |
| Catalytic activity: | |
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; |
| Subunit: | |
The phosphorylated form forms a complex with WNK2 (PubMed:21733846). Interacts with RELT (PubMed:16530727). Interacts with SORL1 (via cytosolic C-terminus) (By similarity). {ECO:0000250|UniProtKB:Q9UEW8, ECO:0000269|PubMed:16530727, ECO:0000269|PubMed:21733846}. |
| Subcellular location: | |
Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Nucleus when caspase-cleaved. {ECO:0000305}. |
| Tissue specificity: | |
Expressed in the kidney, including in epithelial cells of the thick ascending limb of Henle's loop and in the distal convoluted tubule (at protein level). {ECO:0000269|PubMed:20385770}. |
| Domain: | |
PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins. |
| Ptm: | |
Phosphorylated at Ser-321 by PRKCQ (PubMed:21733846). Autophosphorylation at Thr-243 positively regulates its activity (PubMed:16530727). {ECO:0000269|PubMed:16530727, ECO:0000269|PubMed:21733846}. |
| Similarity: | |
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.