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UniProt functional annotation for Q9BV86 | ||
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| UniProt code: Q9BV86. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Distributive alpha-N-methyltransferase that methylates the N- terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]- Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. {ECO:0000269|PubMed:20481588, ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:24090352, ECO:0000269|PubMed:26543159}. |
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| Catalytic activity: | |
Reaction=N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl- L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl- L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54712, Rhea:RHEA-COMP:13785, Rhea:RHEA-COMP:13971, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:138057, ChEBI:CHEBI:138315; EC=2.1.1.244; Evidence={ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:26543159}; |
| Catalytic activity: | |
Reaction=N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl- L-methionine = 3 H(+) + N-terminal N,N,N-trimethyl-L-seryl-L-prolyl- L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54724, Rhea:RHEA-COMP:13789, Rhea:RHEA-COMP:13973, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:138061, ChEBI:CHEBI:138317; EC=2.1.1.244; Evidence={ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:26543159}; |
| Catalytic activity: | |
Reaction=N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl- L-methionine = 2 H(+) + N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L- lysyl-[protein] + 2 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:54736, Rhea:RHEA-COMP:13787, Rhea:RHEA-COMP:13974, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:138059, ChEBI:CHEBI:138318; EC=2.1.1.244; Evidence={ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:26543159}; |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:20668449, ECO:0000269|PubMed:24090352}. Note=Predominantly nuclear (PubMed:24090352). |
| Similarity: | |
Belongs to the methyltransferase superfamily. NTM1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.