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UniProt functional annotation for Q6P179 | ||
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| UniProt code: Q6P179. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. {ECO:0000269|PubMed:12799365, ECO:0000269|PubMed:15908954, ECO:0000269|PubMed:16286653}. |
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| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250}; |
| Subunit: | |
Heterodimer with ERAP1. {ECO:0000269|PubMed:15908954, ECO:0000269|PubMed:22106953}. |
| Subcellular location: | |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:12799365}; Single-pass type II membrane protein {ECO:0000269|PubMed:12799365}. |
| Tissue specificity: | |
Ubiquitously expressed. Highly expressed in spleen and leukocytes. {ECO:0000269|PubMed:12799365}. |
| Induction: | |
By IFNG/IFN-gamma. {ECO:0000269|PubMed:15691326, ECO:0000269|PubMed:15908954}. |
| Ptm: | |
N-glycosylated. {ECO:0000269|PubMed:12799365, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:22106953}. |
| Miscellaneous: | |
Defects in the expression of this gene may cause improper antigen processing, possibly leading to favor tumor escape from the immune surveillance. |
| Similarity: | |
Belongs to the peptidase M1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.