 |
PDBsum entry 5ctc
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Transferase/transferase inhibitor
|
PDB id
|
|
|
|
5ctc
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
References listed in PDB file
|
|
|
Key reference
|
|
|
Title
|
|
Discovery of spirocyclic-Diamine inhibitors of mammalian acetyl CoA-Carboxylase.
|
|
|
Authors
|
|
D.W.Kung,
D.A.Griffith,
W.P.Esler,
F.F.Vajdos,
A.M.Mathiowetz,
S.D.Doran,
P.A.Amor,
S.W.Bagley,
T.Banks,
S.Cabral,
K.Ford,
C.N.Garcia-Irizarry,
M.S.Landis,
K.Loomis,
K.Mcpherson,
M.Niosi,
K.L.Rockwell,
C.Rose,
A.C.Smith,
J.A.Southers,
S.Tapley,
M.Tu,
J.J.Valentine.
|
|
|
Ref.
|
|
Bioorg Med Chem Lett, 2015,
25,
5352-5356.
[DOI no: ]
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
A novel series of spirocyclic-diamine based, isoform non-selective inhibitors of
acetyl-CoA carboxylase (ACC) is described. These spirodiamine derivatives were
discovered by design of a library to mimic the structural rigidity and
hydrogen-bonding pattern observed in the co-crystal structure of spirochromanone
inhibitor I. The lead compound 3.5.1 inhibited de novo lipogenesis in rat
hepatocytes, with an IC50 of 0.30μM.
|
|
|
|
|
|
|
