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UniProt functional annotation for P17846 | ||
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| UniProt code: P17846. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. {ECO:0000255|HAMAP-Rule:MF_01540}. |
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| Catalytic activity: | |
Reaction=3 H2O + hydrogen sulfide + 3 NADP(+) = 4 H(+) + 3 NADPH + sulfite; Xref=Rhea:RHEA:13801, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17359, ChEBI:CHEBI:29919, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.8.1.2; Evidence={ECO:0000255|HAMAP- Rule:MF_01540}; |
| Cofactor: | |
Name=siroheme; Xref=ChEBI:CHEBI:60052; Evidence={ECO:0000255|HAMAP-Rule:MF_01540, ECO:0000269|PubMed:7569952, ECO:0000269|PubMed:9315848}; Note=Binds 1 siroheme per subunit. {ECO:0000255|HAMAP-Rule:MF_01540, ECO:0000269|PubMed:7569952, ECO:0000269|PubMed:9315848}; |
| Cofactor: | |
Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000255|HAMAP-Rule:MF_01540, ECO:0000269|PubMed:7569952, ECO:0000269|PubMed:9315848}; Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO:0000255|HAMAP- Rule:MF_01540, ECO:0000269|PubMed:7569952, ECO:0000269|PubMed:9315848}; |
| Pathway: | |
Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1. {ECO:0000255|HAMAP- Rule:MF_01540}. |
| Subunit: | |
Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein. {ECO:0000255|HAMAP-Rule:MF_01540}. |
| Similarity: | |
Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAA23651.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA68816.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.