|
|
||
|
|
|
|
|
UniProt functional annotation for P34913 | ||
|
|
|
|
|
|
||
| UniProt code: P34913. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12869654, PubMed:12574510, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady- state levels of physiological mediators (PubMed:12869654, PubMed:12574510, PubMed:22798687, PubMed:21217101). {ECO:0000250|UniProtKB:P80299, ECO:0000269|PubMed:12574508, ECO:0000269|PubMed:12574510, ECO:0000269|PubMed:12869654, ECO:0000269|PubMed:21217101, ECO:0000269|PubMed:22798687}. |
|
||
|
||
| Function: | |
Bifunctional enzyme (PubMed:12574510). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro- 9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec- 9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed:12574510). Has phosphatase activity toward lyso- glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates (PubMed:22217705, PubMed:22387545). {ECO:0000269|PubMed:12574510, ECO:0000269|PubMed:22217705, ECO:0000269|PubMed:22387545}. |
|
||
| Catalytic activity: | |
Reaction=an epoxide + H2O = an ethanediol; Xref=Rhea:RHEA:19037, ChEBI:CHEBI:15377, ChEBI:CHEBI:32955, ChEBI:CHEBI:140594; EC=3.3.2.10; Evidence={ECO:0000269|PubMed:12574510, ECO:0000269|PubMed:12869654, ECO:0000269|PubMed:22798687}; |
| Catalytic activity: | |
Reaction=(9S,10S)-10-hydroxy-9-(phosphooxy)octadecanoate + H2O = (9S,10S)-9,10-dihydroxyoctadecanoate + phosphate; Xref=Rhea:RHEA:16537, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58796, ChEBI:CHEBI:58797; EC=3.1.3.76; Evidence={ECO:0000269|PubMed:12574508, ECO:0000269|PubMed:12574510, ECO:0000269|PubMed:15196990}; |
| Catalytic activity: | |
Reaction=12-phosphooxy-(9Z)-octadecenoate + H2O = 12-hydroxy-(9Z)- octadecenoate + phosphate; Xref=Rhea:RHEA:45272, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:85141, ChEBI:CHEBI:85150; Evidence={ECO:0000269|PubMed:12574510}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45273; Evidence={ECO:0000269|PubMed:12574510}; |
| Catalytic activity: | |
Reaction=12-phosphooxy-(9E)-octadecenoate + H2O = 12-hydroxy-(9E)- octadecenoate + phosphate; Xref=Rhea:RHEA:45276, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:85137, ChEBI:CHEBI:85152; Evidence={ECO:0000269|PubMed:12574510}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45277; Evidence={ECO:0000269|PubMed:12574510}; |
| Catalytic activity: | |
Reaction=12-(phosphooxy)octadecanoate + H2O = 12-hydroxyoctadecanoate + phosphate; Xref=Rhea:RHEA:45280, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:84201, ChEBI:CHEBI:85134; Evidence={ECO:0000269|PubMed:12574510}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:45281; Evidence={ECO:0000269|PubMed:12574510}; |
| Catalytic activity: | |
Reaction=8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = 8,9-dihydroxy- (5Z,11Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:44048, ChEBI:CHEBI:15377, ChEBI:CHEBI:84025, ChEBI:CHEBI:84032; Evidence={ECO:0000269|PubMed:22798687}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44049; Evidence={ECO:0000305|PubMed:22798687}; |
| Catalytic activity: | |
Reaction=11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = 11,12- dihydroxy-(5Z,8Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:44044, ChEBI:CHEBI:15377, ChEBI:CHEBI:76625, ChEBI:CHEBI:84031; Evidence={ECO:0000269|PubMed:22798687}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44045; Evidence={ECO:0000305|PubMed:22798687}; |
| Catalytic activity: | |
Reaction=14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = 14,15- dihydroxy-(5Z,8Z,11Z)-eicosatrienoate; Xref=Rhea:RHEA:44040, ChEBI:CHEBI:15377, ChEBI:CHEBI:84024, ChEBI:CHEBI:84029; Evidence={ECO:0000269|PubMed:22798687}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44041; Evidence={ECO:0000305|PubMed:22798687}; |
| Catalytic activity: | |
Reaction=9,10-epoxy-(12Z)-octadecenoate + H2O = 9,10-dihydroxy-(12Z)- octadecenoate; Xref=Rhea:RHEA:44032, ChEBI:CHEBI:15377, ChEBI:CHEBI:84023, ChEBI:CHEBI:84027; Evidence={ECO:0000269|PubMed:22798687}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44033; Evidence={ECO:0000305|PubMed:22798687}; |
| Catalytic activity: | |
Reaction=8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate + H2O = (8,11R,12S)-trihydroxy-(5Z,9E,14Z)-eicosatrienoate; Xref=Rhea:RHEA:50896, ChEBI:CHEBI:15377, ChEBI:CHEBI:78100, ChEBI:CHEBI:132127; Evidence={ECO:0000269|PubMed:21217101}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50897; Evidence={ECO:0000269|PubMed:21217101}; |
| Catalytic activity: | |
Reaction=10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O = (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:50900, ChEBI:CHEBI:15377, ChEBI:CHEBI:78084, ChEBI:CHEBI:78099; Evidence={ECO:0000269|PubMed:21217101}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50901; Evidence={ECO:0000269|PubMed:21217101}; |
| Catalytic activity: | |
Reaction=1-tetradecanoyl-sn-glycerol 3-phosphate + H2O = 1- tetradecanoyl-sn-glycerol + phosphate; Xref=Rhea:RHEA:53592, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:72683, ChEBI:CHEBI:75536; Evidence={ECO:0000269|PubMed:22387545}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53593; Evidence={ECO:0000269|PubMed:22387545}; |
| Catalytic activity: | |
Reaction=1-octadecanoyl-sn-glycero-3-phosphate + H2O = 1-octadecanoyl- sn-glycerol + phosphate; Xref=Rhea:RHEA:53596, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:74565, ChEBI:CHEBI:75550; Evidence={ECO:0000269|PubMed:22217705, ECO:0000269|PubMed:22387545}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53597; Evidence={ECO:0000269|PubMed:22217705, ECO:0000269|PubMed:22387545}; |
| Catalytic activity: | |
Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:53600, ChEBI:CHEBI:15377, ChEBI:CHEBI:34071, ChEBI:CHEBI:43474, ChEBI:CHEBI:74938; Evidence={ECO:0000269|PubMed:22217705, ECO:0000269|PubMed:22387545}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53601; Evidence={ECO:0000269|PubMed:22217705, ECO:0000269|PubMed:22387545}; |
| Catalytic activity: | |
Reaction=1-hexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl- sn-glycerol + phosphate; Xref=Rhea:RHEA:53604, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57518, ChEBI:CHEBI:75542; Evidence={ECO:0000269|PubMed:22217705, ECO:0000269|PubMed:22387545}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53605; Evidence={ECO:0000269|PubMed:22217705, ECO:0000269|PubMed:22387545}; |
| Catalytic activity: | |
Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 1-(9Z- octadecenoyl)-sn-glycerol + phosphate; Xref=Rhea:RHEA:39835, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:74544, ChEBI:CHEBI:75757; Evidence={ECO:0000269|PubMed:22217705, ECO:0000269|PubMed:22387545}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:39836; Evidence={ECO:0000269|PubMed:22217705, ECO:0000269|PubMed:22387545}; |
| Catalytic activity: | |
Reaction=(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)- dihydroxy-(5Z,11Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:53972, ChEBI:CHEBI:15377, ChEBI:CHEBI:131974, ChEBI:CHEBI:138002; Evidence={ECO:0000250|UniProtKB:P34914}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53973; Evidence={ECO:0000250|UniProtKB:P34914}; |
| Catalytic activity: | |
Reaction=(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)- dihydroxy-(5Z,8Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:53980, ChEBI:CHEBI:15377, ChEBI:CHEBI:131969, ChEBI:CHEBI:138004; Evidence={ECO:0000250|UniProtKB:P34914}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53981; Evidence={ECO:0000250|UniProtKB:P34914}; |
| Catalytic activity: | |
Reaction=(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)- dihydroxy-(5Z,8Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:53984, ChEBI:CHEBI:15377, ChEBI:CHEBI:131969, ChEBI:CHEBI:138005; Evidence={ECO:0000250|UniProtKB:P34914}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53985; Evidence={ECO:0000250|UniProtKB:P34914}; |
| Catalytic activity: | |
Reaction=(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)- dihydroxy-(5Z,8Z,11Z)-eicosatrienoate; Xref=Rhea:RHEA:53992, ChEBI:CHEBI:15377, ChEBI:CHEBI:131964, ChEBI:CHEBI:138003; Evidence={ECO:0000250|UniProtKB:P34914}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53993; Evidence={ECO:0000250|UniProtKB:P34914}; |
| Catalytic activity: | |
Reaction=(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)- dihydroxy-(5Z,8Z,11Z)-eicosatrienoate; Xref=Rhea:RHEA:53996, ChEBI:CHEBI:15377, ChEBI:CHEBI:131964, ChEBI:CHEBI:138006; Evidence={ECO:0000250|UniProtKB:P34914}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53997; Evidence={ECO:0000250|UniProtKB:P34914}; |
| Catalytic activity: | |
Reaction=(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)- dihydroxy-(5Z,8Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:54004, ChEBI:CHEBI:15377, ChEBI:CHEBI:131970, ChEBI:CHEBI:138005; Evidence={ECO:0000250|UniProtKB:P34914}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54005; Evidence={ECO:0000250|UniProtKB:P34914}; |
| Catalytic activity: | |
Reaction=(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)- dihydroxy-(5Z,8Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:54000, ChEBI:CHEBI:15377, ChEBI:CHEBI:131970, ChEBI:CHEBI:138004; Evidence={ECO:0000250|UniProtKB:P34914}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54001; Evidence={ECO:0000250|UniProtKB:P34914}; |
| Catalytic activity: | |
Reaction=(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)- dihydroxy-(5Z,11Z,14Z)-eicosatrienoate; Xref=Rhea:RHEA:54016, ChEBI:CHEBI:15377, ChEBI:CHEBI:131974, ChEBI:CHEBI:138008; Evidence={ECO:0000250|UniProtKB:P34914}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:54017; Evidence={ECO:0000250|UniProtKB:P34914}; |
| Catalytic activity: | |
Reaction=(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)- dihydroxy-(5Z,8Z,11Z)-eicosatrienoate; Xref=Rhea:RHEA:53976, ChEBI:CHEBI:15377, ChEBI:CHEBI:131965, ChEBI:CHEBI:138003; Evidence={ECO:0000250|UniProtKB:P34914}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53977; Evidence={ECO:0000250|UniProtKB:P34914}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:12574510, ECO:0000269|PubMed:15096040, ECO:0000269|PubMed:16322563}; |
| Activity regulation: | |
Inhibited by 1-(1-acetylpiperidin-4-yl)-3-(4- (trifl uoromethoxy)phenyl)urea (TPAU), 1-cyclohexyl-3-dodecylurea (CDU), 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA), 1-((3S, 5S, 7S)-adamantan-1-yl)-3-(5-(2-(2-ethoxyethoxy) ethoxy)pentyl)urea (AEPU), N-adamantyl-N[']-cyclohexyl urea (ACU), 4-(((1S, 4S)-4-(3-((3S, 5S, 7S)-adamantan-1-yl) ureido)cyclohexyl)oxy)benzoic acid (c-AUCB), 4- (((1R, 4R)-4-(3-((3S, 5S, 7S)-adamantan-1- yl)ureido)cyclohexyl)oxy)benzoic acid (t-AUCB), 4-(((1R, 4R)-4-(3- (4(trifluoromethoxy)phenyl)ureido)cyclohexyl)oxy)benzoic acid (t-TAUCB) and to a lesser extent by 8-(3-((3S, 5S, 7S)-adamantan-1-yl)ureido) octanoic acid (AUOA). Phosphatase activity is inhibited by dodecyl- phosphate, phospholipids such as phospho-lysophosphatidic acids and fatty acids such as palmitic acid and lauric acid (PubMed:22217705, PubMed:22387545). {ECO:0000269|PubMed:21217101, ECO:0000269|PubMed:22217705, ECO:0000269|PubMed:22387545, ECO:0000269|PubMed:22798687}. |
| Biophysicochemical properties: | |
Kinetic parameters: KM=21 uM for threo-9,10-phosphonooxy-hydroxy-octadecanoic acid {ECO:0000269|PubMed:12574508, ECO:0000269|PubMed:12574510, ECO:0000269|PubMed:15196990}; KM=1.7 uM for 8,9-EET {ECO:0000269|PubMed:22798687}; KM=3.4 uM for 11,12-EET {ECO:0000269|PubMed:22798687}; KM=15 uM for 14,15-EET {ECO:0000269|PubMed:22798687}; KM=1.5 uM for leukotoxin {ECO:0000269|PubMed:22798687}; KM=1.1 mM for p-nitrophenyl phosphate {ECO:0000269|PubMed:12574508, ECO:0000269|PubMed:12574510, ECO:0000269|PubMed:15196990}; KM=7.3 uM for 8-hydroxy-(11S,12S)-epoxy-(5Z,9E,14Z)-eicosatrienoate {ECO:0000269|PubMed:21217101}; KM=10.8 uM for 10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)- eicosatrienoate {ECO:0000269|PubMed:21217101}; KM=3 uM for palmitoyl-lysophosphatidic acid {ECO:0000269|PubMed:22217705}; KM=6.4 uM for stearoyl-lysophosphatidic acid {ECO:0000269|PubMed:22217705}; KM=6.2 uM for oleoyl-lysophosphatidic acid {ECO:0000269|PubMed:22217705}; KM=5.9 uM for arachidonoyl-lysophosphatidic acid {ECO:0000269|PubMed:22217705}; KM=5.3 uM for arachidoyl-lysophosphatidic acid {ECO:0000269|PubMed:22217705}; KM=23.5 uM for 1-alkyl lysophosphatidic acid (C18:0) {ECO:0000269|PubMed:22217705}; KM=14.8 uM for sphingosine-1-phosphate {ECO:0000269|PubMed:22217705}; KM=20.9 uM for geranylgeranyl pyrophosphate {ECO:0000269|PubMed:22217705}; KM=10 uM for farnesyl pyro-phosphate {ECO:0000269|PubMed:22387545}; KM=5.1 uM for 1-myristoyl-2-hydroxy-3-glycerophosphate {ECO:0000269|PubMed:22387545}; KM=23 uM for 1-palmityl-2-hydroxy-3-glycerophosphate {ECO:0000269|PubMed:22387545}; KM=4.2 uM for 1-stearyl-2-hydroxy-3-glycerophosphate {ECO:0000269|PubMed:22387545}; KM=6.9 uM for 1-oleoyl-2-hydroxy-3-glycerophosphate {ECO:0000269|PubMed:22387545}; KM=13 uM for 1-arachidonoyl-2-hydroxy-3-glycerophosphate {ECO:0000269|PubMed:22387545}; KM=31 uM for shingosine-1-phosphate {ECO:0000269|PubMed:22387545}; KM=67 uM for N-acetyl-ceramide-phosphate {ECO:0000269|PubMed:22387545}; Vmax=338 nmol/min/mg enzyme with threo-9,10-phosphonooxy-hydroxy- octadecanoic acid {ECO:0000269|PubMed:12574508, ECO:0000269|PubMed:12574510, ECO:0000269|PubMed:15196990}; Vmax=0.9 umol/min/mg enzyme with 8,9-EET as substrate {ECO:0000269|PubMed:22798687}; Vmax=4.5 umol/min/mg enzyme with 11,12-EET as substrate {ECO:0000269|PubMed:22798687}; Vmax=7 umol/min/mg enzyme with 14,15-EET as substrate {ECO:0000269|PubMed:22798687}; Vmax=0.55 umol/min/mg enzyme with leukotoxin as substrate {ECO:0000269|PubMed:22798687}; Vmax=5.8 nmol/min/mg enzyme with p-nitrophenyl phosphate {ECO:0000269|PubMed:12574508, ECO:0000269|PubMed:12574510, ECO:0000269|PubMed:15196990}; Vmax=385 nmol/min/mg enzyme with 8-hydroxy-(11S,12S)-epoxy- (5Z,9E,14Z)-eicosatrienoate as substrate {ECO:0000269|PubMed:21217101}; Vmax=95 nmol/min/mg enzyme with 10-hydroxy-(11S,12S)- epoxy- (5Z,8Z,14Z)-eicosatrienoate as substrate {ECO:0000269|PubMed:21217101}; Vmax=150.4 nmol/min/mg enzyme with palmitoyl-lysophosphatidic acid as substrate {ECO:0000269|PubMed:22217705}; Vmax=193.5 nmol/min/mg enzyme with stearoyl-lysophosphatidic acid as substrate {ECO:0000269|PubMed:22217705}; Vmax=191.6 nmol/min/mg enzyme with oleoyl-lysophosphatidic acid as substrate {ECO:0000269|PubMed:22217705}; Vmax=157.9 nmol/min/mg enzyme with arachidonoyl-lysophosphatidic acid as substrate {ECO:0000269|PubMed:22217705}; Vmax=26.8 nmol/min/mg enzyme with arachidoyl-lysophosphatidic acid as substrate {ECO:0000269|PubMed:22217705}; Vmax=171.1 nmol/min/mg enzyme with 1-alkyl lysophosphatidic acid (C18:0) as substrate {ECO:0000269|PubMed:22217705}; Vmax=60.6 nmol/min/mg enzyme with sphingosine-1-phosphate as substrate {ECO:0000269|PubMed:22217705}; Vmax=101.3 nmol/min/mg enzyme with geranylgeranyl pyrophosphate as substrate {ECO:0000269|PubMed:22217705}; Note=kcat are 14 sec(-1), 354 sec(-1), 167 sec(-1), 125 sec(-1), 177 sec(-1), 250 sec(-1), 18 sec(-1) and 136 sec(-1) for farnesyl pyro- phosphate, 1-myristoyl-2-hydroxy-3-glycerophosphate, 1-palmityl-2- hydroxy-3-glycerophosphate, 1-stearyl-2-hydroxy-3-glycerophosphate, 1-oleoyl-2-hydroxy-3-glycerophosphate, 1-arachidonoyl-2-hydroxy-3- glycerophosphate, shingosine-1-phosphate and N-acetyl-ceramide- phosphate, respectively. {ECO:0000269|PubMed:22387545}; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:15096040, ECO:0000269|PubMed:19969453, ECO:0000269|PubMed:20934334}. |
| Subcellular location: | |
Cytoplasm. Peroxisome. |
| Induction: | |
By compounds that cause peroxisome proliferation such as clofibrate, tiadenol and fenofibrate. |
| Domain: | |
The N-terminal domain has phosphatase activity. The C-terminal domain has epoxide hydrolase activity. |
| Ptm: | |
The N-terminus is blocked. |
| Ptm: | |
The covalent modification of cysteine by 15-deoxy-Delta12,14- prostaglandin-J2 is autocatalytic and reversible. It may occur as an alternative to other cysteine modifications, such as S-nitrosylation and S-palmitoylation (Probable). {ECO:0000305}. |
| Similarity: | |
Belongs to the AB hydrolase superfamily. Epoxide hydrolase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.