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UniProt functional annotation for Q9I739 | ||
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| UniProt code: Q9I739. |
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| Organism: | |
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. |
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| Function: | |
Type VI secretion exported toxin that acts as a glycohydrolase on bacterial target cells and degrades the essential dinucleotides NAD(+) and NADP(+), thereby inducing bacteriostasis. The activity resides in the C-terminal region that is initially neutralized by the cognate immunity protein Tsi6. {ECO:0000269|PubMed:26456113, ECO:0000269|PubMed:30177742}. |
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| Catalytic activity: | |
Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide; Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.5; Evidence={ECO:0000269|PubMed:26456113}; |
| Subunit: | |
Interacts with Tsi6, VgrG1a, EagT6 and EF-Tu. {ECO:0000269|PubMed:26456113}. |
| Subcellular location: | |
Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. |
Annotations taken from UniProtKB at the EBI.