UniProt functional annotation for Q9K492



	UniProt functional annotation for Q9K492

UniProt code: Q9K492.

Organism: Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).

Taxonomy: Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.

Function: Global regulator that is part of the nutrient-sensing system. In the absence of glucosamine 6-P (GlcN6P), represses the phosphotransferase system (PTS) specific for the uptake of N- acetylglucosamine (PTSNag), and genes involved in the metabolism of chitin, as well as several genes involved in development, thereby linking carbon availability to morphogenesis (PubMed:15247334, PubMed:16925557). Also regulates the expression of the ABC transporters DasABC and NgcEFG, which are involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake (PubMed:17351098, PubMed:30089751). Binds to the DNA consensus sequence 5'-ACTGGTCTAGACCACT-3' (PubMed:15247334, PubMed:16925557). {ECO:0000269|PubMed:15247334, ECO:0000269|PubMed:16925557, ECO:0000269|PubMed:17351098, ECO:0000269|PubMed:30089751}.

Activity regulation: Binding to the target genes is abolished by GlcN6P, a central molecule in N-acetylglucosamine metabolism. {ECO:0000269|PubMed:16925557}.

Subcellular location: Cytoplasm {ECO:0000305}.

Induction: Induced by (GlcNAc)2 and (GlcNAc)3. {ECO:0000269|PubMed:17351098}.

Disruption phenotype: Deletion of the gene results in a bald phenotype, mutant fails to produce aerial hyphae and spores on glucose-containig media. The mutant is arrested at an early stage of the developmental program. {ECO:0000269|PubMed:16925557}.

Annotations taken from UniProtKB at the EBI.


Organism:		Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
Taxonomy:		Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.



Function:		Global regulator that is part of the nutrient-sensing system. In the absence of glucosamine 6-P (GlcN6P), represses the phosphotransferase system (PTS) specific for the uptake of N- acetylglucosamine (PTSNag), and genes involved in the metabolism of chitin, as well as several genes involved in development, thereby linking carbon availability to morphogenesis (PubMed:15247334, PubMed:16925557). Also regulates the expression of the ABC transporters DasABC and NgcEFG, which are involved in N,N'-diacetylchitobiose ((GlcNAc)2) uptake (PubMed:17351098, PubMed:30089751). Binds to the DNA consensus sequence 5'-ACTGGTCTAGACCACT-3' (PubMed:15247334, PubMed:16925557). {ECO:0000269\|PubMed:15247334, ECO:0000269\|PubMed:16925557, ECO:0000269\|PubMed:17351098, ECO:0000269\|PubMed:30089751}.


Activity regulation:		Binding to the target genes is abolished by GlcN6P, a central molecule in N-acetylglucosamine metabolism. {ECO:0000269\|PubMed:16925557}.
Subcellular location:		Cytoplasm {ECO:0000305}.
Induction:		Induced by (GlcNAc)2 and (GlcNAc)3. {ECO:0000269\|PubMed:17351098}.
Disruption phenotype:		Deletion of the gene results in a bald phenotype, mutant fails to produce aerial hyphae and spores on glucose-containig media. The mutant is arrested at an early stage of the developmental program. {ECO:0000269\|PubMed:16925557}.