UniProt functional annotation for B3BM81



	UniProt functional annotation for B3BM81

UniProt code: B3BM81.

Organism: Escherichia coli O157:H7 (strain EC869).

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.

Function: Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion (PubMed:21829394). Neutralizes the toxic activity of cognate toxin CdiA-o11-EC869 (the C-terminal 289 residue CT fragment). Does not inhibit toxic activity of CdiA from other toxin- immunity modules or strains of E.coli (PubMed:21829394, PubMed:26305955) (Probable). {ECO:0000269|PubMed:21829394, ECO:0000269|PubMed:26305955, ECO:0000305|PubMed:23236156, ECO:0000305|PubMed:26449640}.

Function: Expression of this locus confers protection against other bacteria carrying the locus. {ECO:0000269|PubMed:21829394}.

Subunit: Interacts with the C-terminal fragment (CT, residues 88-377) of cognate toxin protein CdiA-o11-EC869 (PubMed:21829394, PubMed:23236156, PubMed:26449640). Probably recognizes only the toxic DNase subdomain of CdiA-o11-EC869 (approximately residues 222-377) (Probable). {ECO:0000269|PubMed:21829394, ECO:0000269|PubMed:23236156, ECO:0000269|PubMed:26449640, ECO:0000305|PubMed:26305955}.

Annotations taken from UniProtKB at the EBI.


Organism:		Escherichia coli O157:H7 (strain EC869).
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.



Function:		Immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring bacteria in a contact-dependent fashion (PubMed:21829394). Neutralizes the toxic activity of cognate toxin CdiA-o11-EC869 (the C-terminal 289 residue CT fragment). Does not inhibit toxic activity of CdiA from other toxin- immunity modules or strains of E.coli (PubMed:21829394, PubMed:26305955) (Probable). {ECO:0000269\|PubMed:21829394, ECO:0000269\|PubMed:26305955, ECO:0000305\|PubMed:23236156, ECO:0000305\|PubMed:26449640}.



Function:		Expression of this locus confers protection against other bacteria carrying the locus. {ECO:0000269\|PubMed:21829394}.


Subunit:		Interacts with the C-terminal fragment (CT, residues 88-377) of cognate toxin protein CdiA-o11-EC869 (PubMed:21829394, PubMed:23236156, PubMed:26449640). Probably recognizes only the toxic DNase subdomain of CdiA-o11-EC869 (approximately residues 222-377) (Probable). {ECO:0000269\|PubMed:21829394, ECO:0000269\|PubMed:23236156, ECO:0000269\|PubMed:26449640, ECO:0000305\|PubMed:26305955}.