UniProt functional annotation for Q8BR65



	UniProt functional annotation for Q8BR65

UniProt code: Q8BR65.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). {ECO:0000250|UniProtKB:Q9H7L9, ECO:0000269|PubMed:11909966}.

Subunit: Interacts with HCFC1 (By similarity). Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with USP17L2; the interaction is direct (By similarity). Interacts with FOXK2 (By similarity). {ECO:0000250|UniProtKB:Q9H7L9}.

Subcellular location: Nucleus {ECO:0000250|UniProtKB:Q9H7L9}.

Tissue specificity: Expressed in all newborn tissues tested, including brain, kidney and liver. {ECO:0000269|PubMed:11909966}.

Domain: The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms. {ECO:0000250|UniProtKB:Q9H7L9}.

Ptm: Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains (By similarity). {ECO:0000250|UniProtKB:Q9H7L9}.

Similarity: Belongs to the SDS3 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). {ECO:0000250\|UniProtKB:Q9H7L9, ECO:0000269\|PubMed:11909966}.


Subunit:		Interacts with HCFC1 (By similarity). Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with USP17L2; the interaction is direct (By similarity). Interacts with FOXK2 (By similarity). {ECO:0000250\|UniProtKB:Q9H7L9}.
Subcellular location:		Nucleus {ECO:0000250\|UniProtKB:Q9H7L9}.
Tissue specificity:		Expressed in all newborn tissues tested, including brain, kidney and liver. {ECO:0000269\|PubMed:11909966}.
Domain:		The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms. {ECO:0000250\|UniProtKB:Q9H7L9}.
Ptm:		Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains (By similarity). {ECO:0000250\|UniProtKB:Q9H7L9}.
Similarity:		Belongs to the SDS3 family. {ECO:0000305}.