UniProt functional annotation for P78285

UniProt code: P78285.

Organism: Escherichia coli (strain K12).
Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.
 
Function: Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity. Exhibits lytic activity against E.coli and S.typhi cell wall substrate. {ECO:0000269|PubMed:17914239}.
 
Catalytic activity: Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17;
Disruption phenotype: Mutants are unable to form wild-type biofilms, which could be due to altered peptidoglycan metabolism. {ECO:0000269|PubMed:21415116}.
Miscellaneous: Encoded by the cryptic lambdoid prophage DLP12.
Similarity: Belongs to the glycosyl hydrolase 24 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.