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UniProt functional annotation for P42527 | ||
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| UniProt code: P42527. |
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| Organism: | |
Dictyostelium discoideum (Slime mold). |
| Taxonomy: | |
Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; Dictyosteliaceae; Dictyostelium. |
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| Function: | |
Phosphorylates threonine in the C-terminal tail region of myosin II heavy chain. This phosphorylation is critical in regulating the assembly and disassembly of myosin II filament. Requires autophosphorylation for activity. |
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| Catalytic activity: | |
Reaction=ATP + L-threonyl-[myosin heavy-chain] = ADP + H(+) + O- phospho-L-threonyl-[myosin heavy-chain]; Xref=Rhea:RHEA:11424, Rhea:RHEA-COMP:13718, Rhea:RHEA-COMP:13719, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.7; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
| Subunit: | |
Oligomer. |
| Ptm: | |
The N-terminus is blocked. |
| Similarity: | |
Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.