UniProt functional annotation for Q6L8Q7



	UniProt functional annotation for Q6L8Q7

UniProt code: Q6L8Q7.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:30389976, PubMed:26055709). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709). {ECO:0000269|PubMed:15231837, ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541, ECO:0000269|PubMed:26055709, ECO:0000269|PubMed:30389976}.

Catalytic activity: Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; Evidence={ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541, ECO:0000269|PubMed:26055709, ECO:0000269|PubMed:30389976};

Cofactor: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:22285541, ECO:0000269|PubMed:26055709, ECO:0000269|Ref.16};

Biophysicochemical properties: pH dependence: Optimum pH is 8.0 for 2'-5' oligoadenylate exonuclease activity. {ECO:0000269|PubMed:22285541};

Subcellular location: Mitochondrion matrix {ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541}.

Tissue specificity: Ubiquitous. {ECO:0000269|PubMed:15231837}.

Similarity: Belongs to the CCR4/nocturin family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:30389976, PubMed:26055709). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709). {ECO:0000269\|PubMed:15231837, ECO:0000269\|PubMed:21245038, ECO:0000269\|PubMed:21666256, ECO:0000269\|PubMed:22285541, ECO:0000269\|PubMed:26055709, ECO:0000269\|PubMed:30389976}.


Catalytic activity:		Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; Evidence={ECO:0000269\|PubMed:21245038, ECO:0000269\|PubMed:21666256, ECO:0000269\|PubMed:22285541, ECO:0000269\|PubMed:26055709, ECO:0000269\|PubMed:30389976};
Cofactor:		Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269\|PubMed:22285541, ECO:0000269\|PubMed:26055709, ECO:0000269\|Ref.16};
Biophysicochemical properties:		pH dependence: Optimum pH is 8.0 for 2'-5' oligoadenylate exonuclease activity. {ECO:0000269\|PubMed:22285541};
Subcellular location:		Mitochondrion matrix {ECO:0000269\|PubMed:21245038, ECO:0000269\|PubMed:21666256, ECO:0000269\|PubMed:22285541}.
Tissue specificity:		Ubiquitous. {ECO:0000269\|PubMed:15231837}.
Similarity:		Belongs to the CCR4/nocturin family. {ECO:0000305}.