UniProt functional annotation for Q08491



	UniProt functional annotation for Q08491

UniProt code: Q08491.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Represses the expression of non-poly(A) mRNAs like L-A or M viruses and is therefore involved in antiviral system. Mediates interactions via its N-terminus between the exosome and the SKI complex which operate in the 3'-to-5' mRNA-decay pathway. By interacting with NAM7, is also required for nonsense-mediated 3'-to-5' mRNA-decay (NMD). May recognize a stalled 80S ribosome at the 3'-end of a nonstop mRNA which leads to the recruitment of the exosome and SKI complexes to the mRNAs to be degraded. {ECO:0000269|PubMed:10074137, ECO:0000269|PubMed:11027292, ECO:0000269|PubMed:11514438, ECO:0000269|PubMed:11532933, ECO:0000269|PubMed:11910110, ECO:0000269|PubMed:12769863, ECO:0000269|PubMed:12881429, ECO:0000269|PubMed:14671320, ECO:0000269|PubMed:15933721, ECO:0000269|PubMed:6371496}.

Subunit: Interacts with the exosome and with the SKI complex composed of at least SKI2, SKI3 and SKI8. Interacts directly with SKI3 and SKI8. {ECO:0000269|PubMed:11532933, ECO:0000269|PubMed:11910110, ECO:0000269|PubMed:12881429, ECO:0000269|PubMed:16043509, ECO:0000269|PubMed:17173052}.

Subcellular location: Cytoplasm {ECO:0000269|PubMed:11532933, ECO:0000269|PubMed:12730603}.

Domain: The N-terminal domain (residues 1 to 264) is required and sufficient for interaction with the exosome and SKI complexes and for 3'-to-5' mRNA degradation. {ECO:0000269|PubMed:11532933}.

Miscellaneous: Present with 233 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.

Similarity: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. {ECO:0000255|PROSITE-ProRule:PRU01059}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Represses the expression of non-poly(A) mRNAs like L-A or M viruses and is therefore involved in antiviral system. Mediates interactions via its N-terminus between the exosome and the SKI complex which operate in the 3'-to-5' mRNA-decay pathway. By interacting with NAM7, is also required for nonsense-mediated 3'-to-5' mRNA-decay (NMD). May recognize a stalled 80S ribosome at the 3'-end of a nonstop mRNA which leads to the recruitment of the exosome and SKI complexes to the mRNAs to be degraded. {ECO:0000269\|PubMed:10074137, ECO:0000269\|PubMed:11027292, ECO:0000269\|PubMed:11514438, ECO:0000269\|PubMed:11532933, ECO:0000269\|PubMed:11910110, ECO:0000269\|PubMed:12769863, ECO:0000269\|PubMed:12881429, ECO:0000269\|PubMed:14671320, ECO:0000269\|PubMed:15933721, ECO:0000269\|PubMed:6371496}.


Subunit:		Interacts with the exosome and with the SKI complex composed of at least SKI2, SKI3 and SKI8. Interacts directly with SKI3 and SKI8. {ECO:0000269\|PubMed:11532933, ECO:0000269\|PubMed:11910110, ECO:0000269\|PubMed:12881429, ECO:0000269\|PubMed:16043509, ECO:0000269\|PubMed:17173052}.
Subcellular location:		Cytoplasm {ECO:0000269\|PubMed:11532933, ECO:0000269\|PubMed:12730603}.
Domain:		The N-terminal domain (residues 1 to 264) is required and sufficient for interaction with the exosome and SKI complexes and for 3'-to-5' mRNA degradation. {ECO:0000269\|PubMed:11532933}.
Miscellaneous:		Present with 233 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity:		Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. {ECO:0000255\|PROSITE-ProRule:PRU01059}.