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UniProt functional annotation for P29508 | ||
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| UniProt code: P29508. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1). {ECO:0000269|PubMed:19166818}. |
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| Subunit: | |
Interacts with MAPK8/JNK1. {ECO:0000269|PubMed:19166818}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:10956412, ECO:0000269|PubMed:14970861}. Note=Seems to also be secreted in plasma by cancerous cells but at a low level. |
| Tissue specificity: | |
Squamous cells. Expressed in some hepatocellular carcinoma (at protein level). {ECO:0000269|PubMed:14970861}. |
| Developmental stage: | |
Its expression is closely related to cellular differentiation in both normal and malignant squamous cells. |
| Induction: | |
Strongly up-regulated in the upper epidermis of sun-exposed skin. {ECO:0000269|PubMed:19166818}. |
| Similarity: | |
Belongs to the serpin family. Ov-serpin subfamily. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAO11731.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.