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UniProt functional annotation for O14977 | ||
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| UniProt code: O14977. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). {ECO:0000269|PubMed:17900240, ECO:0000269|PubMed:26305948}. |
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| Subunit: | |
Monomer (PubMed:26305948). Interacts with OAZ1 and OAZ3; this interaction disrupts the interaction between the antizyme and ODC1 (Probable). {ECO:0000269|PubMed:26305948, ECO:0000305|PubMed:26305948}. |
| Subcellular location: | |
Nucleus {ECO:0000250|UniProtKB:O35484}. |
| Tissue specificity: | |
Expressed in liver. {ECO:0000269|PubMed:9349715}. |
| Ptm: | |
Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1. {ECO:0000269|PubMed:17900240}. |
| Similarity: | |
Belongs to the Orn/Lys/Arg decarboxylase class-II family. ODC antizyme inhibitor subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.