PDBsum entry 4zdr

Protein binding

PDB id: 4zdr

Contents

Protein chains

243 a.a.

Ligands

GOL ×3

SO4 ×2

TME ×6

Waters ×8

References listed in PDB file

Key reference

• Title: Structure of the 14-3-3ζ-Lkb1 fusion protein provides insight into a novel ligand-Binding mode of 14-3-3.
• Authors: S.Ding, R.Zhou, Y.Zhu.
• Ref.: Acta Crystallogr F Struct Biol Commun, 2015, 71, 1114-1119. [DOI no: 10.1107/S2053230X15012595]
• PubMed id: 26323294

Abstract

The 14-3-3 proteins are a family of highly conserved proteins that play key roles in many cellular processes. The tumour suppressor LKB1 regulates cell polarity, cell growth and energy metabolism. 14-3-3 proteins bind to LKB1 and suppress its functions. Previously, preliminary crystallographic data for the 14-3-3ζ-LKB1 fusion protein have been reported. Here, the crystal structure of this fusion protein was solved and a novel potential binding mode of 14-3-3 to its ligands was found.