PDBsum entry 4z9m

Transferase

PDB id: 4z9m

Contents

Protein chains

352 a.a.

300 a.a.

375 a.a.

313 a.a.

Ligands

ADP ×8

UNX ×71

Waters ×849

PDB id:

4z9m

Name:

Transferase

Title:

Crystal structure of human sarcomeric mitochondrial creatine kinase

Structure:

Creatine kinase s-type, mitochondrial. Chain: a, b, c, d, e, f, g, h. Fragment: unp residues 27-416. Synonym: basic-type mitochondrial creatine kinase,mib-ck,sarcomeric mitochondrial creatine kinase,s-mtck. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ckmt2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.10Å R-factor: 0.203 R-free: 0.236

Authors:

W.M.Rabeh,W.Tempel,L.Nedyalkova,R.Landry,C.H.Arrowsmith,A.M.Edwards, C.Bountra,A.Bochkarev,H.Park,Structural Genomics Consortium (Sgc)

Key ref:

W.M.Rabeh et al. Crystal structure of human sarcomeric mitochondrial c kinase. To be published, .

Date:

10-Apr-15 Release date: 22-Apr-15

Supersedes:

2gl6

Protein chain

P17540  (KCRS_HUMAN) -  Creatine kinase S-type, mitochondrial from Homo sapiens

Seq: 419 a.a.

Struc: 352 a.a.

Protein chain

P17540  (KCRS_HUMAN) -  Creatine kinase S-type, mitochondrial from Homo sapiens

Seq: 419 a.a.

Struc: 300 a.a.*

Protein chains

P17540  (KCRS_HUMAN) -  Creatine kinase S-type, mitochondrial from Homo sapiens

Seq: 419 a.a.

Struc: 375 a.a.

Protein chain

P17540  (KCRS_HUMAN) -  Creatine kinase S-type, mitochondrial from Homo sapiens

Seq: 419 a.a.

Struc: 313 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B, C, D, E, F, G, H: E.C.2.7.3.2 - creatine kinase.
• Pathway: Creatine Biosynthesis
• Reaction: creatine + ATP = N-phosphocreatine + ADP + H⁺

creatine + ATP = N-phosphocreatine (Bound ligand (Het Group name = ADP) corresponds exactly) + ADP + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site