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UniProt functional annotation for P24666 | ||
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| UniProt code: P24666. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity. |
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| Catalytic activity: | |
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; |
| Catalytic activity: | |
Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2; |
| Activity regulation: | |
Inhibited by sulfhydryl reagents. |
| Subunit: | |
Isoform 1 interacts with the SH3 domain of SPTAN1. There is no interaction observed for isoforms 2 or 3. Interacts with EPHA2; dephosphorylates EPHA2. Interacts with EPHB1. {ECO:0000269|PubMed:11971983, ECO:0000269|PubMed:12167657, ECO:0000269|PubMed:9499402}. |
| Subcellular location: | |
Cytoplasm. |
| Tissue specificity: | |
T-lymphocytes express only isoform 2. {ECO:0000269|PubMed:9038134}. |
| Polymorphism: | |
ACP1 is genetically polymorphic. Three common alleles are known in Caucasians: ACP1*A, ACP1*B and ACP1*C. They give rise to six different phenotypes. Each allele appears to encode two electrophoretically different isozymes, F and S, which are produced in allele-specific ratios (PubMed:1939112). The sequence shown is that of allele ACP1*B and allele ACP1*C. {ECO:0000269|PubMed:1939112}. |
| Similarity: | |
Belongs to the low molecular weight phosphotyrosine protein phosphatase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.