|
|
||
|
|
|
|
|
UniProt functional annotation for Q59961 | ||
|
|
|
|
|
|
||
| UniProt code: Q59961. |
|
||
| Organism: | |
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus. |
|
||
|
||
| Function: | |
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. {ECO:0000255|HAMAP- Rule:MF_00939, ECO:0000269|PubMed:17375187, ECO:0000269|PubMed:20596531}. |
|
||
| Catalytic activity: | |
Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000255|HAMAP-Rule:MF_00939, ECO:0000269|PubMed:17375187, ECO:0000269|PubMed:20596531}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_00939, ECO:0000269|PubMed:20596531}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|HAMAP-Rule:MF_00939, ECO:0000269|PubMed:20596531}; Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000255|HAMAP-Rule:MF_00939, ECO:0000269|PubMed:20596531}; Note=Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+). {ECO:0000255|HAMAP-Rule:MF_00939, ECO:0000269|PubMed:20596531}; |
| Activity regulation: | |
Inhibited by quinolones, such as levofloxacin. {ECO:0000269|PubMed:20596531}. |
| Subunit: | |
Heterotetramer composed of ParC and ParE. {ECO:0000255|HAMAP- Rule:MF_00939, ECO:0000269|PubMed:17375187, ECO:0000269|PubMed:19448616, ECO:0000269|PubMed:20596531}. |
| Similarity: | |
Belongs to the type II topoisomerase family. ParE type 2 subfamily. {ECO:0000255|HAMAP-Rule:MF_00939}. |
Annotations taken from UniProtKB at the EBI.