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UniProt functional annotation for P72525 | ||
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| UniProt code: P72525. |
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| Organism: | |
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus. |
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| Function: | |
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA (PubMed:17375187, PubMed:20596531). Performs the decatenation events required during the replication of a circular DNA molecule. {ECO:0000255|HAMAP-Rule:MF_00937, ECO:0000269|PubMed:17375187, ECO:0000269|PubMed:20596531}. |
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| Catalytic activity: | |
Reaction=ATP-dependent breakage, passage and rejoining of double- stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000255|HAMAP-Rule:MF_00937, ECO:0000269|PubMed:17375187, ECO:0000269|PubMed:20596531}; |
| Activity regulation: | |
Inhibited by quinolones, such as levofloxacin (PubMed:20596531). {ECO:0000269|PubMed:20596531}. |
| Subunit: | |
Heterotetramer composed of ParC and ParE (PubMed:17375187, PubMed:20596531). {ECO:0000255|HAMAP-Rule:MF_00937, ECO:0000269|PubMed:17375187, ECO:0000269|PubMed:20596531}. |
| Subcellular location: | |
Cell membrane {ECO:0000255|HAMAP-Rule:MF_00937}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_00937}. |
| Similarity: | |
Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. {ECO:0000255|HAMAP-Rule:MF_00937}. |
Annotations taken from UniProtKB at the EBI.