PDBsum entry 4z25

Oxidoreductase

PDB id: 4z25

Contents

Protein chains

(+ 6 more) 649 a.a.

Ligands

FAD ×12

References listed in PDB file

Key reference

• Title: A mimivirus enzyme that participates in viral entry.
• Authors: T.Klose, D.A.Herbst, H.Zhu, J.P.Max, H.I.Kenttämaa, M.G.Rossmann.
• Ref.: Structure, 2015, 23, 1058-1065. [DOI no: 10.1016/j.str.2015.03.023]
• PubMed id: 25982526

Abstract

Mimivirus was initially identified as a bacterium because its dense, 125-nm-long fibers stained Gram-positively. These fibers probably play a role during the infection of some host cells. The normal hosts of Mimivirus are unknown, but in the laboratory Mimivirus is usually propagated in amoeba. The structure of R135, a major component of the fibrous outer layer of Mimivirus, has been determined to 2-Å resolution. The protein's structure is similar to that of members of the glucose-methanol-choline oxidoreductase family, which have an N-terminal FAD binding domain and a C-terminal substrate recognition domain. The closest homolog to R135 is an aryl-alcohol oxidase that participates in lignin biodegradation of plant cell walls. Thus R135 might participate in the degradation of their normal hosts, including some lignin-containing algae.