UniProt functional annotation for Q9Y2H2



	UniProt functional annotation for Q9Y2H2

UniProt code: Q9Y2H2.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869669}.

Catalytic activity: Reaction=a myo-inositol phosphate + H2O = myo-inositol + phosphate; Xref=Rhea:RHEA:24056, ChEBI:CHEBI:15377, ChEBI:CHEBI:17268, ChEBI:CHEBI:43474, ChEBI:CHEBI:84139; EC=3.1.3.25; Evidence={ECO:0000269|PubMed:25869668, ECO:0000269|PubMed:25869669};

Biophysicochemical properties: Kinetic parameters: KM=14.3 uM for PtdIns(4,5)P2 (at pH 6.0) {ECO:0000269|PubMed:11274189};

Subunit: Homodimer (PubMed:25869669). Interacts with OCRL and RAB5A (PubMed:25869668). Interacts with INPP5B and INPP4A (PubMed:25869668). Interacts with STAT3; the interaction is independent of STAT3 'TYR-705' phosphorylation status (PubMed:25476455). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869668, ECO:0000269|PubMed:25869669}.

Subcellular location: Membrane, clathrin-coated pit {ECO:0000269|PubMed:25869669}. Early endosome {ECO:0000269|PubMed:25869669}. Recycling endosome {ECO:0000269|PubMed:25869669}. Note=Also found on macropinosomes. {ECO:0000250|UniProtKB:Q8CDA1}.

Tissue specificity: Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138). {ECO:0000269|PubMed:11274189, ECO:0000269|PubMed:26203138}.

Sequence caution: Sequence=BAA76810.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). {ECO:0000250\|UniProtKB:Q8CDA1, ECO:0000269\|PubMed:17322895, ECO:0000269\|PubMed:25476455, ECO:0000269\|PubMed:25869669}.


Catalytic activity:		Reaction=a myo-inositol phosphate + H2O = myo-inositol + phosphate; Xref=Rhea:RHEA:24056, ChEBI:CHEBI:15377, ChEBI:CHEBI:17268, ChEBI:CHEBI:43474, ChEBI:CHEBI:84139; EC=3.1.3.25; Evidence={ECO:0000269\|PubMed:25869668, ECO:0000269\|PubMed:25869669};
Biophysicochemical properties:		Kinetic parameters: KM=14.3 uM for PtdIns(4,5)P2 (at pH 6.0) {ECO:0000269\|PubMed:11274189};
Subunit:		Homodimer (PubMed:25869669). Interacts with OCRL and RAB5A (PubMed:25869668). Interacts with INPP5B and INPP4A (PubMed:25869668). Interacts with STAT3; the interaction is independent of STAT3 'TYR-705' phosphorylation status (PubMed:25476455). {ECO:0000250\|UniProtKB:Q8CDA1, ECO:0000269\|PubMed:25476455, ECO:0000269\|PubMed:25869668, ECO:0000269\|PubMed:25869669}.
Subcellular location:		Membrane, clathrin-coated pit {ECO:0000269\|PubMed:25869669}. Early endosome {ECO:0000269\|PubMed:25869669}. Recycling endosome {ECO:0000269\|PubMed:25869669}. Note=Also found on macropinosomes. {ECO:0000250\|UniProtKB:Q8CDA1}.
Tissue specificity:		Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138). {ECO:0000269\|PubMed:11274189, ECO:0000269\|PubMed:26203138}.
Sequence caution:		Sequence=BAA76810.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};